biostudies-literatureBalas MCNational Center for Advancing Translational SciencesNCATS NIH HHSAmerican Association of Critical-Care NursesSociety of Critical Care MedicineNIA NIH HHSNational Heart, Lung, and Blood InstituteNHLBI NIH HHSGordon and Betty Moore FoundationNational Institutes of Health588-602https://www.ebi.ac.uk/biostudies/studies/S-EPMC9470738biostudies-literatureUnknown162(3)<h4>Background</h4>Broad-scale adoption of spontaneous awakening trials (SATs) and spontaneous breathing trials (SBTs) into everyday practice has been slow, and uncertainty exists regarding what factors facilitate or impede their routine delivery.<h4>Research question</h4>What patient, practice, and pharmacologic factors are associated with SAT and SBT performance and to what extent do they predict overall SAT/SBT performance?<h4>Study design and methods</h4>This secondary analysis used data collected from a national quality improvement collaborative composed of 68 diverse ICUs. Adults with critical illness adults who received mechanical ventilation and/or continuously infused sedative medications were included. We performed mixed-effects logistic regression modeling, created receiver operChestFactors Associated With Spontaneous Awakening Trial and Spontaneous Breathing Trial Performance in Adults With Critical Illness: Analysis of a Multicenter, Nationwide, Cohort Study.PMC9470738R03AG063276R01 HL146781UL1 TR000445R01HL14678-01R03 AG063276R01HL14678R01 AG062685R01AG062685Jun JPun BVasilevskis EEBalas MCMu JMion LCEly EWBrockman ATan AfalseFactors Associated With Spontaneous Awakening Trial and Spontaneous Breathing Trial Performance in Adults With Critical Illness: Analysis of a Multicenter, Nationwide, Cohort Study.<h4>Background</h4>Broad-scale adoption of spontaneous awakening trials (SATs) and spontaneous breathing trials (SBTs) into everyday practice has been slow, and uncertainty exists regarding what factors facilitate or impede their routine delivery.<h4>Research question</h4>What patient, practice, and pharmacologic factors are associated with SAT and SBT performance and to what extent do they predict overall SAT/SBT performance?<h4>Study design and methods</h4>This secondary analysis used data collected from a national quality improvement collaborative composed of 68 diverse ICUs. Adults with critical illness adults who received mechanical ventilation and/or continuously infused sedative medications were included. We performed mixed-effects logistic regression modeling, created receiver oper2022-01-01T00:00:00Z2022 Sep2025-04-04T20:04:19.92Z2025-04-04T20:04:19.92ZS-EPMC94707383506345310.1016/j.chest.2022.01.018