{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Singh AK"],"funding":["Ministry of Health"],"pagination":["e13675"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9470894"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(9)"],"pubmed_abstract":["The master epigenetic regulator lysine acetyltransferase (KAT) p300/CBP plays a pivotal role in neuroplasticity and cognitive functions. Recent evidence has shown that in several neurodegenerative diseases, including Alzheimer's disease (AD), the expression level and function of p300/CBP are severely compromised, leading to altered gene expression causing pathological conditions. Here, we show that p300/CBP activation by a small-molecule TTK21, conjugated to carbon nanosphere (CSP) ameliorates Aβ-impaired long-term potentiation (LTP) induced by high-frequency stimulation, theta burst stimulation, and synaptic tagging/capture (STC). This functional rescue was correlated with CSP-TTK21-induced changes in transcription and translation. Mechanistically, we observed that the expression of a lar"],"journal":["Aging cell"],"pubmed_title":["Glucose derived carbon nanosphere (CSP) conjugated TTK21, an activator of the histone acetyltransferases CBP/p300, ameliorates amyloid-beta 1-42 induced deficits in plasticity and associativity in hippocampal CA1 pyramidal neurons."],"pmcid":["PMC9470894"],"funding_grant_id":["MOH‐000641‐00"],"pubmed_authors":["Pavon MV","Sajikumar S","Neo SH","Liwang C","Rao VJ","Joshi I","Vasudevan M","Sheila AR","Sinha SH","Singh AK","Shetty MS","Leng JCK","Eswaramoorthy M","Pang KKL","Navakkode S","Kundu TK"],"additional_accession":[]},"is_claimable":false,"name":"Glucose derived carbon nanosphere (CSP) conjugated TTK21, an activator of the histone acetyltransferases CBP/p300, ameliorates amyloid-beta 1-42 induced deficits in plasticity and associativity in hippocampal CA1 pyramidal neurons.","description":"The master epigenetic regulator lysine acetyltransferase (KAT) p300/CBP plays a pivotal role in neuroplasticity and cognitive functions. Recent evidence has shown that in several neurodegenerative diseases, including Alzheimer's disease (AD), the expression level and function of p300/CBP are severely compromised, leading to altered gene expression causing pathological conditions. Here, we show that p300/CBP activation by a small-molecule TTK21, conjugated to carbon nanosphere (CSP) ameliorates Aβ-impaired long-term potentiation (LTP) induced by high-frequency stimulation, theta burst stimulation, and synaptic tagging/capture (STC). This functional rescue was correlated with CSP-TTK21-induced changes in transcription and translation. Mechanistically, we observed that the expression of a lar","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2026-06-20T03:25:27.45Z","creation":"2025-04-04T20:19:39.542Z"},"accession":"S-EPMC9470894","cross_references":{"pubmed":["35962576"],"doi":["10.1111/acel.13675"]}}