{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["21(9)"],"submitter":["Siino V"],"funding":["Lunds Universitet"],"pubmed_abstract":["The study of healthy human aging is important for shedding light on the molecular mechanisms behind aging to promote well-being and to possibly predict and/or avoid the development of age-related disorders such as atherosclerosis and diabetes. Herein, we have employed an untargeted mass spectrometry-based approach to study age-related protein changes in a healthy Sicilian plasma cohort including long-lived individuals. This approach confirmed some of the previously known proteins correlated with age including fibulin-1, dystroglycan, and gamma-glutamyl hydrolase. Furthermore, our findings include novel proteins that correlate with age and/or with location and uric acid, which could represent a unique signature for healthy aging."],"journal":["Aging cell"],"pagination":["e13684"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9470904"],"repository":["biostudies-literature"],"pubmed_title":["Plasma proteome profiling of healthy individuals across the life span in a Sicilian cohort with long-lived individuals."],"pmcid":["PMC9470904"],"pubmed_authors":["Ligotti ME","Siino V","Accardi G","Levander F","Ali A","Caruso C","Aiello A","Candore G","Vasto S","Mosquim Junior S"],"additional_accession":[]},"is_claimable":false,"name":"Plasma proteome profiling of healthy individuals across the life span in a Sicilian cohort with long-lived individuals.","description":"The study of healthy human aging is important for shedding light on the molecular mechanisms behind aging to promote well-being and to possibly predict and/or avoid the development of age-related disorders such as atherosclerosis and diabetes. Herein, we have employed an untargeted mass spectrometry-based approach to study age-related protein changes in a healthy Sicilian plasma cohort including long-lived individuals. This approach confirmed some of the previously known proteins correlated with age including fibulin-1, dystroglycan, and gamma-glutamyl hydrolase. Furthermore, our findings include novel proteins that correlate with age and/or with location and uric acid, which could represent a unique signature for healthy aging.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2026-05-28T00:35:08.658Z","creation":"2025-04-04T14:20:56.232Z"},"accession":"S-EPMC9470904","cross_references":{"pubmed":["35932462"],"doi":["10.1111/acel.13684"]}}