biostudies-literatureUnknown21(9)Siino VLunds UniversitetThe study of healthy human aging is important for shedding light on the molecular mechanisms behind aging to promote well-being and to possibly predict and/or avoid the development of age-related disorders such as atherosclerosis and diabetes. Herein, we have employed an untargeted mass spectrometry-based approach to study age-related protein changes in a healthy Sicilian plasma cohort including long-lived individuals. This approach confirmed some of the previously known proteins correlated with age including fibulin-1, dystroglycan, and gamma-glutamyl hydrolase. Furthermore, our findings include novel proteins that correlate with age and/or with location and uric acid, which could represent a unique signature for healthy aging.Aging celle13684https://www.ebi.ac.uk/biostudies/studies/S-EPMC9470904biostudies-literaturePlasma proteome profiling of healthy individuals across the life span in a Sicilian cohort with long-lived individuals.PMC9470904Ligotti MESiino VAccardi GLevander FAli ACaruso CAiello ACandore GVasto SMosquim Junior SfalsePlasma proteome profiling of healthy individuals across the life span in a Sicilian cohort with long-lived individuals.The study of healthy human aging is important for shedding light on the molecular mechanisms behind aging to promote well-being and to possibly predict and/or avoid the development of age-related disorders such as atherosclerosis and diabetes. Herein, we have employed an untargeted mass spectrometry-based approach to study age-related protein changes in a healthy Sicilian plasma cohort including long-lived individuals. This approach confirmed some of the previously known proteins correlated with age including fibulin-1, dystroglycan, and gamma-glutamyl hydrolase. Furthermore, our findings include novel proteins that correlate with age and/or with location and uric acid, which could represent a unique signature for healthy aging.2022-01-01T00:00:00Z2022 Sep2026-05-28T00:35:08.658Z2025-04-04T14:20:56.232ZS-EPMC94709043593246210.1111/acel.13684