{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(14)"],"submitter":["Mei S"],"pubmed_abstract":["<b>Background:</b> Mechanical ventilation (MV) can induce pulmonary fibrosis. This study aims to investigate whether MV-induced pulmonary fibrosis is associated with aerobic glycolysis and seeks to uncover the underlying mechanisms mediated by integrin β3-pyruvate kinase M2 (PKM2) pathway. <b>Methods:</b> PKM2 knockdown or inhibition, integrin β3 knockout or inhibition and wild-type mice were exposed to MV (20 mL/kg) for 2 h. <b>Results:</b> Mice exposed to MV exhibited increased expression of collagen deposition, and upregulation of α-smooth muscle actin and collagen I in lung tissues. Single cells analysis showed that MV-induced pulmonary fibrosis was associated with increased gene expression of integrin and glycolysis in pulmonary fibroblasts, as well as upregulation of glycolytic produ"],"journal":["Theranostics"],"pagination":["6057-6068"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9475464"],"repository":["biostudies-literature"],"pubmed_title":["Integrin β3-PKM2 pathway-mediated aerobic glycolysis contributes to mechanical ventilation-induced pulmonary fibrosis."],"pmcid":["PMC9475464"],"pubmed_authors":["Hu Y","Feng J","He Z","Xu Q","Mei S","Xing S","Gao Y","Tang R","Zhou Y"],"additional_accession":[]},"is_claimable":false,"name":"Integrin β3-PKM2 pathway-mediated aerobic glycolysis contributes to mechanical ventilation-induced pulmonary fibrosis.","description":"<b>Background:</b> Mechanical ventilation (MV) can induce pulmonary fibrosis. This study aims to investigate whether MV-induced pulmonary fibrosis is associated with aerobic glycolysis and seeks to uncover the underlying mechanisms mediated by integrin β3-pyruvate kinase M2 (PKM2) pathway. <b>Methods:</b> PKM2 knockdown or inhibition, integrin β3 knockout or inhibition and wild-type mice were exposed to MV (20 mL/kg) for 2 h. <b>Results:</b> Mice exposed to MV exhibited increased expression of collagen deposition, and upregulation of α-smooth muscle actin and collagen I in lung tissues. Single cells analysis showed that MV-induced pulmonary fibrosis was associated with increased gene expression of integrin and glycolysis in pulmonary fibroblasts, as well as upregulation of glycolytic produ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-06-18T07:05:59.592Z","creation":"2025-04-19T22:47:02.611Z"},"accession":"S-EPMC9475464","cross_references":{"pubmed":["36168620"],"doi":["10.7150/thno.72328"]}}