{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Johnson RK"],"funding":["NHLBI NIH HHS","NIH HHS"],"pagination":["965-971.e8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9475490"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["150(4)"],"pubmed_abstract":["<h4>Background</h4>Lipid mediators, bioactive products of polyunsaturated fatty acid metabolism, contribute to inflammation initiation and resolution in allergic diseases; however, their presence in lung-related biosamples has not been fully described.<h4>Objective</h4>We aimed to quantify lipid mediators in the nasal airway epithelium and characterize preliminary associations with asthma.<h4>Methods</h4>Using liquid chromatography-mass spectrometry, we conducted a pilot study to quantify 56 lipid mediators from nasal epithelial samples collected from 11 female participants of an outpatient asthma clinic and community controls (aged 30-55 years). We examined the presence of each compound using descriptive statistics to test whether lipid mediators could distinguish subjects with asthma (n "],"journal":["The Journal of allergy and clinical immunology"],"pubmed_title":["Lipid mediators are detectable in the nasal epithelium and differ by asthma status in female subjects."],"pmcid":["PMC9475490"],"funding_grant_id":["R01 HL123385","R01 HL104608","S10 OD010366"],"pubmed_authors":["Mathias RA","Boorgula MP","Cruz A","Reisdorph N","Johnson RK","Manke J","Barnes KC","Santana CVN","Armstrong M","Campbell M","Pinheiro G","Figueiredo CA"],"additional_accession":[]},"is_claimable":false,"name":"Lipid mediators are detectable in the nasal epithelium and differ by asthma status in female subjects.","description":"<h4>Background</h4>Lipid mediators, bioactive products of polyunsaturated fatty acid metabolism, contribute to inflammation initiation and resolution in allergic diseases; however, their presence in lung-related biosamples has not been fully described.<h4>Objective</h4>We aimed to quantify lipid mediators in the nasal airway epithelium and characterize preliminary associations with asthma.<h4>Methods</h4>Using liquid chromatography-mass spectrometry, we conducted a pilot study to quantify 56 lipid mediators from nasal epithelial samples collected from 11 female participants of an outpatient asthma clinic and community controls (aged 30-55 years). We examined the presence of each compound using descriptive statistics to test whether lipid mediators could distinguish subjects with asthma (n ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-25T21:23:54.779Z","creation":"2025-04-06T08:45:56.748Z"},"accession":"S-EPMC9475490","cross_references":{"pubmed":["35304161"],"doi":["10.1016/j.jaci.2022.02.026"]}}