biostudies-literatureJohnson RKNHLBI NIH HHSNIH HHS965-971.e8https://www.ebi.ac.uk/biostudies/studies/S-EPMC9475490biostudies-literatureUnknown150(4)<h4>Background</h4>Lipid mediators, bioactive products of polyunsaturated fatty acid metabolism, contribute to inflammation initiation and resolution in allergic diseases; however, their presence in lung-related biosamples has not been fully described.<h4>Objective</h4>We aimed to quantify lipid mediators in the nasal airway epithelium and characterize preliminary associations with asthma.<h4>Methods</h4>Using liquid chromatography-mass spectrometry, we conducted a pilot study to quantify 56 lipid mediators from nasal epithelial samples collected from 11 female participants of an outpatient asthma clinic and community controls (aged 30-55 years). We examined the presence of each compound using descriptive statistics to test whether lipid mediators could distinguish subjects with asthma (n The Journal of allergy and clinical immunologyLipid mediators are detectable in the nasal epithelium and differ by asthma status in female subjects.PMC9475490R01 HL123385R01 HL104608S10 OD010366Mathias RABoorgula MPCruz AReisdorph NJohnson RKManke JBarnes KCSantana CVNArmstrong MCampbell MPinheiro GFigueiredo CAfalseLipid mediators are detectable in the nasal epithelium and differ by asthma status in female subjects.<h4>Background</h4>Lipid mediators, bioactive products of polyunsaturated fatty acid metabolism, contribute to inflammation initiation and resolution in allergic diseases; however, their presence in lung-related biosamples has not been fully described.<h4>Objective</h4>We aimed to quantify lipid mediators in the nasal airway epithelium and characterize preliminary associations with asthma.<h4>Methods</h4>Using liquid chromatography-mass spectrometry, we conducted a pilot study to quantify 56 lipid mediators from nasal epithelial samples collected from 11 female participants of an outpatient asthma clinic and community controls (aged 30-55 years). We examined the presence of each compound using descriptive statistics to test whether lipid mediators could distinguish subjects with asthma (n 2022-01-01T00:00:00Z2022 Oct2025-04-25T21:23:54.779Z2025-04-06T08:45:56.748ZS-EPMC94754903530416110.1016/j.jaci.2022.02.026