{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ghuwalewala S"],"funding":["National Institute of Arthritis and Musculoskeletal and Skin Diseases","NCRR NIH HHS","NIAMS NIH HHS"],"pagination":["e110488"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9475544"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["41(18)"],"pubmed_abstract":["Adulte interfollicular epidermis (IFE) renewal is likely orchestrated by physiological demands of its complex tissue architecture comprising spatial and cellular heterogeneity. Mouse tail and back skin display two kinds of basal IFE spatial domains that regenerate at different rates. Here, we elucidate the molecular and cellular states of basal IFE domains by marker expression and single-cell transcriptomics in mouse and human skin. We uncover two paths of basal cell differentiation that in part reflect the IFE spatial domain organization. We unravel previously unrecognized similarities between mouse tail IFE basal domains defined as scales and interscales versus human rete ridges and inter-ridges, respectively. Furthermore, our basal IFE transcriptomics and gene targeting in mice provide "],"journal":["The EMBO journal"],"pubmed_title":["Binary organization of epidermal basal domains highlights robustness to environmental exposure."],"pmcid":["PMC9475544"],"funding_grant_id":["S10 RR025502","R01AR073806","R01 AR073806","R01 AR070157","R01AR070157"],"pubmed_authors":["Jiang K","Tumbar T","Kaur P","Lee SA","Baidya J","Ghuwalewala S","Shalloway D","Chovatiya G"],"additional_accession":[]},"is_claimable":false,"name":"Binary organization of epidermal basal domains highlights robustness to environmental exposure.","description":"Adulte interfollicular epidermis (IFE) renewal is likely orchestrated by physiological demands of its complex tissue architecture comprising spatial and cellular heterogeneity. Mouse tail and back skin display two kinds of basal IFE spatial domains that regenerate at different rates. Here, we elucidate the molecular and cellular states of basal IFE domains by marker expression and single-cell transcriptomics in mouse and human skin. We uncover two paths of basal cell differentiation that in part reflect the IFE spatial domain organization. We unravel previously unrecognized similarities between mouse tail IFE basal domains defined as scales and interscales versus human rete ridges and inter-ridges, respectively. Furthermore, our basal IFE transcriptomics and gene targeting in mice provide ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2026-07-14T15:36:40.38Z","creation":"2025-04-04T20:07:31.984Z"},"accession":"S-EPMC9475544","cross_references":{"pubmed":["35949182"],"doi":["10.15252/embj.2021110488"]}}