{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liang MY"],"funding":["Hubei Province International Science and Technology Cooperation Project","Fundamental Research Funds for the Central Universities","Program for Chongqing Overseas Returnees","Chongqing Talents of Exceptional Young Talents Project, China","Innovation Platform for Academicians of Hainan Province","National Natural Science Foundation of China"],"pagination":["e2203353"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9475545"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(26)"],"pubmed_abstract":["Effective pyroptosis induction is a promising approach to potentiate cancer immunotherapy. However, the actual efficacy of the present pyroptosis inducers can be weakened by successive biological barriers. Here, a cascaded pH-activated supramolecular nanoprodrug (PDNP) with a stepwise size shrinkage property is developed as a pyroptosis inducer to boost antitumor immune response. PDNPs comprise multiple poly(ethylene glycol) (PEG) and doxorubicin (DOX) drug-polymer hybrid repeating blocks conjugated by ultra-pH-sensitive benzoic imine (bzi) and hydrazone (hyd) bonds. The PEG units endow its \"stealth\" property and ensure sufficient tumor accumulation. A sharp switch in particle size and detachment of PEG shielding can be triggered by the acidic extracellular pH to achieve deep intratumor pe"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Stepwise Size Shrinkage Cascade-Activated Supramolecular Prodrug Boosts Antitumor Immunity by Eliciting Pyroptosis."],"pmcid":["PMC9475545"],"funding_grant_id":["CQYC202005029","SQ2021PTZ0024","81874131","51703187","82072996","cstc2021ycjh-bgzxm0061","2042021kf0216","32071375","cx2021017","2021EHB027"],"pubmed_authors":["Sun ZJ","Qiu W","Liang MY","Zhang MJ","Kang YJ","Ye MJ","Xue P","Xiao Y","Xu Z"],"additional_accession":[]},"is_claimable":false,"name":"Stepwise Size Shrinkage Cascade-Activated Supramolecular Prodrug Boosts Antitumor Immunity by Eliciting Pyroptosis.","description":"Effective pyroptosis induction is a promising approach to potentiate cancer immunotherapy. However, the actual efficacy of the present pyroptosis inducers can be weakened by successive biological barriers. Here, a cascaded pH-activated supramolecular nanoprodrug (PDNP) with a stepwise size shrinkage property is developed as a pyroptosis inducer to boost antitumor immune response. PDNPs comprise multiple poly(ethylene glycol) (PEG) and doxorubicin (DOX) drug-polymer hybrid repeating blocks conjugated by ultra-pH-sensitive benzoic imine (bzi) and hydrazone (hyd) bonds. The PEG units endow its \"stealth\" property and ensure sufficient tumor accumulation. A sharp switch in particle size and detachment of PEG shielding can be triggered by the acidic extracellular pH to achieve deep intratumor pe","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-04T20:19:44.072Z","creation":"2025-04-04T20:19:44.072Z"},"accession":"S-EPMC9475545","cross_references":{"pubmed":["35869614"],"doi":["10.1002/advs.202203353"]}}