biostudies-literatureNierves LBC Children&apos;s Hospital FoundationCanada Research Chairs ProgramMichael Cuccione FoundationMichael Smith Foundation for Health Research Scholar ProgramMichael Cuccione Childhood Cancer Research ProgramCanadian Institutes of Health ResearchCIHR56https://www.ebi.ac.uk/biostudies/studies/S-EPMC9476264biostudies-literatureUnknown11(1)<h4>Background</h4>The bone marrow is the place of hematopoiesis with a microenvironment that supports lifelong maintenance of stem cells and high proliferation. It is not surprising that this environment is also favourable for malignant cells emerging in the bone marrow or metastasizing to it. While the cellular composition of the bone marrow microenvironment has been extensively studied, the extracellular matrix and interstitial fluid components have received little attention. Since the sinusoids connect the bone marrow interstitial fluid to the circulation, it is often considered to have the same composition as peripheral blood plasma. Stark differences in the cellular composition of the bone marrow and peripheral blood with different secretory capacities would however suggest profound Experimental hematology & oncologyMulti-omic profiling of the leukemic microenvironment shows bone marrow interstitial fluid is distinct from peripheral blood plasma.PMC9476264PJT-169190Bush JWGuo JHuan TUzozie ACNierves LLange PFChen STsui JfalseMulti-omic profiling of the leukemic microenvironment shows bone marrow interstitial fluid is distinct from peripheral blood plasma.<h4>Background</h4>The bone marrow is the place of hematopoiesis with a microenvironment that supports lifelong maintenance of stem cells and high proliferation. It is not surprising that this environment is also favourable for malignant cells emerging in the bone marrow or metastasizing to it. While the cellular composition of the bone marrow microenvironment has been extensively studied, the extracellular matrix and interstitial fluid components have received little attention. Since the sinusoids connect the bone marrow interstitial fluid to the circulation, it is often considered to have the same composition as peripheral blood plasma. Stark differences in the cellular composition of the bone marrow and peripheral blood with different secretory capacities would however suggest profound 2022-01-01T00:00:00Z2022 Sep2025-04-19T20:35:48.396Z2024-11-20T21:42:14.648ZS-EPMC94762643610980410.1186/s40164-022-00310-0