biostudies-literatureSu YNational Cancer InstituteNCI NIH HHSNational Institutes of Health795-804https://www.ebi.ac.uk/biostudies/studies/S-EPMC9477449biostudies-literatureUnknown75(5)<h4>Background</h4>Cytomegalovirus (CMV)-seropositive (R+) hematopoietic cell transplant (HCT) recipients have a survival disparity compared with CMV-seronegative recipient/donor (R-D-) pairs. We hypothesized that primary letermovir prophylaxis (LET) may abrogate this disparity. We investigated the relationship between LET and mortality at 1 year post-HCT.<h4>Methods</h4>In this retrospective cohort study, we included adult R-D- or R+ patients who received HCT pre-LET (between 1 January 2013 through 15 December 2017) and post-LET (between 16 December 2017 through December 2019). R+ were categorized by LET receipt as R+/LET or R+/no-LET. Cox proportional hazard models were used to estimate the association of LET with all-cause mortality at 1 year after transplantation.<h4>Results</h4>Of 848Clinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaImpact of Letermovir Primary Cytomegalovirus Prophylaxis on 1-Year Mortality After Allogeneic Hematopoietic Cell Transplantation: A Retrospective Cohort Study.PMC9477449P30 CA008748Tamari RKarantoni ECho CNawar TJakubowski AZavras PHan GPapanicolaou GShaffer BPerales MASu YStern ADumke HGiralt SfalseImpact of Letermovir Primary Cytomegalovirus Prophylaxis on 1-Year Mortality After Allogeneic Hematopoietic Cell Transplantation: A Retrospective Cohort Study.<h4>Background</h4>Cytomegalovirus (CMV)-seropositive (R+) hematopoietic cell transplant (HCT) recipients have a survival disparity compared with CMV-seronegative recipient/donor (R-D-) pairs. We hypothesized that primary letermovir prophylaxis (LET) may abrogate this disparity. We investigated the relationship between LET and mortality at 1 year post-HCT.<h4>Methods</h4>In this retrospective cohort study, we included adult R-D- or R+ patients who received HCT pre-LET (between 1 January 2013 through 15 December 2017) and post-LET (between 16 December 2017 through December 2019). R+ were categorized by LET receipt as R+/LET or R+/no-LET. Cox proportional hazard models were used to estimate the association of LET with all-cause mortality at 1 year after transplantation.<h4>Results</h4>Of 8482022-01-01T00:00:00Z2022 Sep2025-04-19T04:43:06.115Z2025-04-19T04:43:06.115ZS-EPMC94774493497902110.1093/cid/ciab1064