{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhao X"],"funding":["This work was financially supported by Cultivation Fund of National Natural Science Foundation"],"pagination":["1077-1088"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9478015"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(5)"],"pubmed_abstract":["<h4>Background</h4>This study commenced to uncover the role of long non-coding RNA FBXL19 antisense RNA 1 (FBXL19-AS1) in the development of ulcerative colitis (UC) and its possible mechanism.<h4>Methods</h4>FBXL19-AS1 expression in the colonic sigmoid mucosa of UC patients was detected. A colitis model was induced in mice using 5% dextran sodium sulfate. Hematoxylin-eosin staining was performed for histopathological examination. Apoptosis was detected by Tunel staining and tissue fibrosis was detected by immunohistochemistry. Also, intestinal permeability was examined. The concentrations of inflammatory factors IL-1β and IL-18 were detected by enzyme-linked immunosorbent assay. The relationship between FBXL19-AS1, miR-339-3p and RHOB was verified by RNA immunoprecipitation assay and dual "],"journal":["Tissue engineering and regenerative medicine"],"pubmed_title":["Long Noncoding RNA FBXL19-AS1-Mediated Ulcerative Colitis-Associated Intestinal Epithelial Barrier Defect."],"pmcid":["PMC9478015"],"funding_grant_id":["Grant No. qiankehe2018-5764-11"],"pubmed_authors":["Yang LC","Cui DJ","Yuan WQ","Zhao X","Yan F"],"additional_accession":[]},"is_claimable":false,"name":"Long Noncoding RNA FBXL19-AS1-Mediated Ulcerative Colitis-Associated Intestinal Epithelial Barrier Defect.","description":"<h4>Background</h4>This study commenced to uncover the role of long non-coding RNA FBXL19 antisense RNA 1 (FBXL19-AS1) in the development of ulcerative colitis (UC) and its possible mechanism.<h4>Methods</h4>FBXL19-AS1 expression in the colonic sigmoid mucosa of UC patients was detected. A colitis model was induced in mice using 5% dextran sodium sulfate. Hematoxylin-eosin staining was performed for histopathological examination. Apoptosis was detected by Tunel staining and tissue fibrosis was detected by immunohistochemistry. Also, intestinal permeability was examined. The concentrations of inflammatory factors IL-1β and IL-18 were detected by enzyme-linked immunosorbent assay. The relationship between FBXL19-AS1, miR-339-3p and RHOB was verified by RNA immunoprecipitation assay and dual ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-05-18T12:58:12.699Z","creation":"2025-05-18T12:58:12.699Z"},"accession":"S-EPMC9478015","cross_references":{"pubmed":["36048401"],"doi":["10.1007/s13770-022-00479-9"]}}