biostudies-literatureSingla ADivision of ChemistryNational Institute of Allergy and Infectious DiseasesNIAID NIH HHSMen of Distinction40724-40737https://www.ebi.ac.uk/biostudies/studies/S-EPMC9480101biostudies-literatureUnknown14(36)<i>Pseudomonas aeruginosa</i> is the leading nosocomial and community-acquired pathogen causing a plethora of acute and chronic infections. The Centers for Disease Control and Prevention has designated multidrug-resistant isolates of <i>P. aeruginosa</i> as a serious threat. A novel delivery vehicle capable of specifically targeting  <i>P. aeruginosa</i>, and encapsulating antimicrobials, may address the challenges associated with these infections. We have developed hetero-multivalent targeted liposomes functionalized with host cell glycans to increase the delivery of antibiotics to the site of infection. Previously, we have demonstrated that compared with monovalent liposomes, these hetero-multivalent liposomes bind with higher affinity to <i>P. aeruginosa</i>. Here, compared with nontargACS applied materials & interfacesHetero-Multivalent Targeted Liposomal Drug Delivery to Treat <i>Pseudomonas aeruginosa</i> Infections.PMC9480101CHE-1904784R03AI139650R21 AI149383R21AI149383R03 AI139650Chirra BCannon CLChen QHassan AMShah KNSingla ASoutherland MRChapman MJRose REGairola ASimbassa SBIvanov IWu HJSen ABaeza JBasharat ARaina RfalseHetero-Multivalent Targeted Liposomal Drug Delivery to Treat <i>Pseudomonas aeruginosa</i> Infections.<i>Pseudomonas aeruginosa</i> is the leading nosocomial and community-acquired pathogen causing a plethora of acute and chronic infections. The Centers for Disease Control and Prevention has designated multidrug-resistant isolates of <i>P. aeruginosa</i> as a serious threat. A novel delivery vehicle capable of specifically targeting  <i>P. aeruginosa</i>, and encapsulating antimicrobials, may address the challenges associated with these infections. We have developed hetero-multivalent targeted liposomes functionalized with host cell glycans to increase the delivery of antibiotics to the site of infection. Previously, we have demonstrated that compared with monovalent liposomes, these hetero-multivalent liposomes bind with higher affinity to <i>P. aeruginosa</i>. Here, compared with nontarg2022-01-01T00:00:00Z2022 Sep2025-04-04T20:07:50.873Z2025-04-04T20:07:50.873ZS-EPMC94801013601883010.1021/acsami.2c12943