{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Lyu Y"],"funding":["CPRIT","Andrew Sabin Family Award","National Institutes of Health","NIH","Cancer Prevention and Research Institute of Texas","University of Texas Rising STARs program","NCI NIH HHS","University of Texas Health Innovation for Cancer Prevention Research","Cancer Center Support","NIAMS NIH HHS","CPRIT Scholar of Cancer Research","MD Anderson Cancer Center","NIH HHS"],"pubmed_abstract":["Stem cells are fundamental units of tissue remodeling whose functions are dictated by lineage-specific transcription factors. Home to epidermal stem cells and their upward-stratifying progenies, skin relies on its secretory functions to form the outermost protective barrier, of which a transcriptional orchestrator has been elusive. KLF5 is a Krüppel-like transcription factor broadly involved in development and regeneration whose lineage specificity, if any, remains unclear. Here we report KLF5 specifically marks the epidermis, and its deletion leads to skin barrier dysfunction in vivo. Lipid envelopes and secretory lamellar bodies are defective in KLF5-deficient skin, accompanied by preferential loss of complex sphingolipids. KLF5 binds to and transcriptionally regulates genes encoding rat"],"journal":["Genes & development"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9480852"],"repository":["biostudies-literature"],"pubmed_title":["KLF5 governs sphingolipid metabolism and barrier function of the skin."],"pmcid":["PMC9480852"],"funding_grant_id":["1K01AR072132","S10 OD012304","P30CA016672","P30 CA016672","RP130397","K01 AR072132","RP160015","S10OD012304-01","FP00006955"],"pubmed_authors":["Mohanty V","Lorenzi PL","Humphrey E","Zhang J","Lyu Y","Nagarajan P","Wang J","Liu V","Kumar SV","Ge Y","Chen Y","Kim KH","Frontera JK","Song X","Jin K","Xi Y","Grivennikov S","Chen K","Dou J","Deliu L","Veillon LJ","Zamler D","Guan Y","McAndrews KM","Yang YJ"],"additional_accession":[]},"is_claimable":false,"name":"KLF5 governs sphingolipid metabolism and barrier function of the skin.","description":"Stem cells are fundamental units of tissue remodeling whose functions are dictated by lineage-specific transcription factors. Home to epidermal stem cells and their upward-stratifying progenies, skin relies on its secretory functions to form the outermost protective barrier, of which a transcriptional orchestrator has been elusive. KLF5 is a Krüppel-like transcription factor broadly involved in development and regeneration whose lineage specificity, if any, remains unclear. Here we report KLF5 specifically marks the epidermis, and its deletion leads to skin barrier dysfunction in vivo. Lipid envelopes and secretory lamellar bodies are defective in KLF5-deficient skin, accompanied by preferential loss of complex sphingolipids. KLF5 binds to and transcriptionally regulates genes encoding rat","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2026-05-10T06:52:38.738Z","creation":"2025-02-19T03:26:38.598Z"},"accession":"S-EPMC9480852","cross_references":{"pubmed":["36008138"],"doi":["10.1101/gad.349662.122"]}}