biostudies-literatureUnknown18(5)Shoushtari MPasteur Institute of IranFlaviviruses are arthropod-borne viruses (arboviruses) that have been recently considered among the significant public health problems in defined geographical regions. In this line, there have been vaccines approved for some flaviviruses including dengue virus (DENV), Japanese encephalitis virus (JEV), yellow fever virus (YFV), and tick-borne encephalitis virus (TBEV), although the efficiency of such vaccines thought to be questionable. Surprisingly, there are no effective vaccine for many other hazardous flaviviruses, including West Nile and Zika viruses. Furthermore, in spite of approved vaccines for some flaviviruses, for example DENV, alternative prophylactic vaccines seem to be still needed for the protection of a broader population, and it originates from the unsatisfying safety, andHuman vaccines & immunotherapeutics2079323https://www.ebi.ac.uk/biostudies/studies/S-EPMC9481145biostudies-literatureAdenovirus vector-based vaccines as forefront approaches in fighting the battle against flaviviruses.PMC9481145Salehi-Vaziri MArashkia AAzadmanesh KShoushtari MRoohvand FBakhshi HfalseAdenovirus vector-based vaccines as forefront approaches in fighting the battle against flaviviruses.Flaviviruses are arthropod-borne viruses (arboviruses) that have been recently considered among the significant public health problems in defined geographical regions. In this line, there have been vaccines approved for some flaviviruses including dengue virus (DENV), Japanese encephalitis virus (JEV), yellow fever virus (YFV), and tick-borne encephalitis virus (TBEV), although the efficiency of such vaccines thought to be questionable. Surprisingly, there are no effective vaccine for many other hazardous flaviviruses, including West Nile and Zika viruses. Furthermore, in spite of approved vaccines for some flaviviruses, for example DENV, alternative prophylactic vaccines seem to be still needed for the protection of a broader population, and it originates from the unsatisfying safety, and2022-01-01T00:00:00Z2022 Nov2026-07-14T16:02:09.919Z2025-02-19T04:39:13.881ZS-EPMC94811453571427110.1080/21645515.2022.2079323