biostudies-literatureDuindam HBZonMw100513https://www.ebi.ac.uk/biostudies/studies/S-EPMC9482799biostudies-literatureUnknown25<h4>Background and objectives</h4>Long-term cognitive performance data in former critically ill COVID-19 patients are sparse. Current evidence suggests that cognitive decline is related to neuroinflammation, which might be attenuated by COVID-19 related anti-inflammatory therapies. The objective of this prospective cohort study was to study long term cognitive outcomes following severe COVID-19 and the relation to anti-inflammatory therapies.<h4>Methods</h4>Prospective observational cohort of patients that survived an intensive care unit (ICU) admission due to severe COVID-19. Six months after hospital discharge, we extensively assessed both objective cognitive functioning and subjective cognitive complaints. Furthermore, patients were stratified in cohorts according to their anti-inflammaBrain, behavior, & immunity - healthLong-term cognitive performance and its relation to anti-inflammatory therapy in a cohort of survivors of severe COVID-19.PMC948279990715610Kessels RPCPickkers Pvan den Borst BAbdo WFDuindam HBfalseLong-term cognitive performance and its relation to anti-inflammatory therapy in a cohort of survivors of severe COVID-19.<h4>Background and objectives</h4>Long-term cognitive performance data in former critically ill COVID-19 patients are sparse. Current evidence suggests that cognitive decline is related to neuroinflammation, which might be attenuated by COVID-19 related anti-inflammatory therapies. The objective of this prospective cohort study was to study long term cognitive outcomes following severe COVID-19 and the relation to anti-inflammatory therapies.<h4>Methods</h4>Prospective observational cohort of patients that survived an intensive care unit (ICU) admission due to severe COVID-19. Six months after hospital discharge, we extensively assessed both objective cognitive functioning and subjective cognitive complaints. Furthermore, patients were stratified in cohorts according to their anti-inflamma2022-01-01T00:00:00Z2022 Nov2025-04-27T02:55:06.547Z2024-10-15T07:24:13.62ZS-EPMC94827993615920810.1016/j.bbih.2022.100513