{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang Y"],"funding":["Science and Technology Commission of Shanghai Municipality","National Natural Science Foundation of China"],"pagination":["101537"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9483785"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26"],"pubmed_abstract":["<h4>Background</h4>Our preclinical research reveals that radiotherapy (RT) promoted PD-L1 upregulation in tumor tissues and that higher PD-L1 after RT worsened the prognosis through immunosuppression. We sought to validate our experimental results in clinical cohorts and promote clinical application.<h4>Patients and methods</h4>In cohort 1, formalin-fixed paraffin-embedded samples were obtained from 46 HCC patients, 23 of whom received preoperative RT and the other 23 received direct surgery. A prospectively collected database contained 122 HCC patients treated with liver RT were enrolled in cohort 2. Blood samples were taken a day before and two weeks after RT. Patients in cohort 2 were further divided into two groups, exploration (73 patients) and validation (49 patients) groups.<h4>Resu"],"journal":["Translational oncology"],"pubmed_title":["Higher serum sPD-L1 levels after radiotherapy indicate poor outcome in hepatocellular carcinoma patients."],"pmcid":["PMC9483785"],"funding_grant_id":["82073479","20ZR1410600"],"pubmed_authors":["Li Z","Hu Y","Du S","Zhang Y","Yang P","Zeng Z","Chen Y"],"additional_accession":[]},"is_claimable":false,"name":"Higher serum sPD-L1 levels after radiotherapy indicate poor outcome in hepatocellular carcinoma patients.","description":"<h4>Background</h4>Our preclinical research reveals that radiotherapy (RT) promoted PD-L1 upregulation in tumor tissues and that higher PD-L1 after RT worsened the prognosis through immunosuppression. We sought to validate our experimental results in clinical cohorts and promote clinical application.<h4>Patients and methods</h4>In cohort 1, formalin-fixed paraffin-embedded samples were obtained from 46 HCC patients, 23 of whom received preoperative RT and the other 23 received direct surgery. A prospectively collected database contained 122 HCC patients treated with liver RT were enrolled in cohort 2. Blood samples were taken a day before and two weeks after RT. Patients in cohort 2 were further divided into two groups, exploration (73 patients) and validation (49 patients) groups.<h4>Resu","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-26T05:30:04.839Z","creation":"2025-04-06T11:28:37.91Z"},"accession":"S-EPMC9483785","cross_references":{"pubmed":["36115075"],"doi":["10.1016/j.tranon.2022.101537"]}}