{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Krishnadas N"],"funding":["NIA NIH HHS"],"pagination":["1627-1637"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9484111"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["88(4)"],"pubmed_abstract":["<h4>Background</h4>In Alzheimer's disease, heterogeneity has been observed in the postmortem distribution of tau neurofibrillary tangles. Visualizing the topography of tau in vivo may facilitate clinical trials and clinical practice.<h4>Objective</h4>This study aimed to investigate whether tau distribution patterns that are limited to mesial temporal lobe (MTL)/limbic regions, and those that spare MTL regions, can be visually identified using 18F-MK6240, and whether these patterns are associated with different demographic and cognitive profiles.<h4>Methods</h4>Tau 18F-MK6240 PET images of 151 amyloid-β positive participants with mild cognitive impairment (MCI) and dementia were visually rated as: tau negative, limbic predominant (LP), MTL-sparing, and Typical by two readers. Groups were ev"],"journal":["Journal of Alzheimer's disease : JAD"],"pubmed_title":["Visually Identified Tau 18F-MK6240 PET Patterns in Symptomatic Alzheimer's Disease."],"pmcid":["PMC9484111"],"funding_grant_id":["P30 AG062421"],"pubmed_authors":["Bourgeat P","Goh AMY","Burnham SC","Schultz SA","Krishnadas N","Maruff P","Laws SM","Huang K","Lamb F","Villemagne VL","Robertson JS","Masters CL","Dore V","Rowe CC","Bozinovski S"],"additional_accession":[]},"is_claimable":false,"name":"Visually Identified Tau 18F-MK6240 PET Patterns in Symptomatic Alzheimer's Disease.","description":"<h4>Background</h4>In Alzheimer's disease, heterogeneity has been observed in the postmortem distribution of tau neurofibrillary tangles. Visualizing the topography of tau in vivo may facilitate clinical trials and clinical practice.<h4>Objective</h4>This study aimed to investigate whether tau distribution patterns that are limited to mesial temporal lobe (MTL)/limbic regions, and those that spare MTL regions, can be visually identified using 18F-MK6240, and whether these patterns are associated with different demographic and cognitive profiles.<h4>Methods</h4>Tau 18F-MK6240 PET images of 151 amyloid-β positive participants with mild cognitive impairment (MCI) and dementia were visually rated as: tau negative, limbic predominant (LP), MTL-sparing, and Typical by two readers. Groups were ev","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-26T05:30:30.855Z","creation":"2025-04-06T11:28:48.095Z"},"accession":"S-EPMC9484111","cross_references":{"pubmed":["35811517"],"doi":["10.3233/JAD-215558"]}}