biostudies-literatureKrishnadas NNIA NIH HHS1627-1637https://www.ebi.ac.uk/biostudies/studies/S-EPMC9484111biostudies-literatureUnknown88(4)<h4>Background</h4>In Alzheimer's disease, heterogeneity has been observed in the postmortem distribution of tau neurofibrillary tangles. Visualizing the topography of tau in vivo may facilitate clinical trials and clinical practice.<h4>Objective</h4>This study aimed to investigate whether tau distribution patterns that are limited to mesial temporal lobe (MTL)/limbic regions, and those that spare MTL regions, can be visually identified using 18F-MK6240, and whether these patterns are associated with different demographic and cognitive profiles.<h4>Methods</h4>Tau 18F-MK6240 PET images of 151 amyloid-β positive participants with mild cognitive impairment (MCI) and dementia were visually rated as: tau negative, limbic predominant (LP), MTL-sparing, and Typical by two readers. Groups were evJournal of Alzheimer's disease : JADVisually Identified Tau 18F-MK6240 PET Patterns in Symptomatic Alzheimer's Disease.PMC9484111P30 AG062421Bourgeat PGoh AMYBurnham SCSchultz SAKrishnadas NMaruff PLaws SMHuang KLamb FVillemagne VLRobertson JSMasters CLDore VRowe CCBozinovski SfalseVisually Identified Tau 18F-MK6240 PET Patterns in Symptomatic Alzheimer's Disease.<h4>Background</h4>In Alzheimer's disease, heterogeneity has been observed in the postmortem distribution of tau neurofibrillary tangles. Visualizing the topography of tau in vivo may facilitate clinical trials and clinical practice.<h4>Objective</h4>This study aimed to investigate whether tau distribution patterns that are limited to mesial temporal lobe (MTL)/limbic regions, and those that spare MTL regions, can be visually identified using 18F-MK6240, and whether these patterns are associated with different demographic and cognitive profiles.<h4>Methods</h4>Tau 18F-MK6240 PET images of 151 amyloid-β positive participants with mild cognitive impairment (MCI) and dementia were visually rated as: tau negative, limbic predominant (LP), MTL-sparing, and Typical by two readers. Groups were ev2022-01-01T00:00:00Z20222025-04-26T05:30:30.855Z2025-04-06T11:28:48.095ZS-EPMC94841113581151710.3233/JAD-215558