{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(8)"],"submitter":["Garrett SR"],"funding":["Wellcome Trust","Biotechnology and Biological Sciences Research Council"],"pubmed_abstract":["The type VII secretion system (T7SS) is found in many Gram-positive firmicutes and secretes protein toxins that mediate bacterial antagonism. Two T7SS toxins have been identified in <i>Staphylococcus aureus</i>, EsaD a nuclease toxin that is counteracted by the EsaG immunity protein, and TspA, which has membrane depolarising activity and is neutralised by TsaI. Both toxins are polymorphic, and strings of non-identical <i>esaG</i> and <i>tsaI</i> immunity genes are encoded in all <i>S. aureus</i> strains. To investigate the evolution of <i>esaG</i> repertoires, we analysed the sequences of the tandem <i>esaG</i> genes and their encoded proteins. We identified three blocks of high sequence similarity shared by all <i>esaG</i> genes and identified evidence of extensive recombination events be"],"journal":["Microbial genomics"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9484751"],"repository":["biostudies-literature"],"pubmed_title":["Homologous recombination between tandem paralogues drives evolution of a subset of type VII secretion system immunity genes in firmicute bacteria."],"pmcid":["PMC9484751"],"funding_grant_id":["218622/Z/19/Z","110183/A/15/Z","BB/M011186/1","101503/Z/13/Z"],"pubmed_authors":["Palmer T","Dicks J","Mariano G","Garrett SR"],"additional_accession":[]},"is_claimable":false,"name":"Homologous recombination between tandem paralogues drives evolution of a subset of type VII secretion system immunity genes in firmicute bacteria.","description":"The type VII secretion system (T7SS) is found in many Gram-positive firmicutes and secretes protein toxins that mediate bacterial antagonism. Two T7SS toxins have been identified in <i>Staphylococcus aureus</i>, EsaD a nuclease toxin that is counteracted by the EsaG immunity protein, and TspA, which has membrane depolarising activity and is neutralised by TsaI. Both toxins are polymorphic, and strings of non-identical <i>esaG</i> and <i>tsaI</i> immunity genes are encoded in all <i>S. aureus</i> strains. To investigate the evolution of <i>esaG</i> repertoires, we analysed the sequences of the tandem <i>esaG</i> genes and their encoded proteins. We identified three blocks of high sequence similarity shared by all <i>esaG</i> genes and identified evidence of extensive recombination events be","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2026-05-27T11:15:24.043Z","creation":"2024-12-04T07:50:37.449Z"},"accession":"S-EPMC9484751","cross_references":{"pubmed":["35960642"],"doi":["10.1099/mgen.0.000868"]}}