{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["25(10)"],"submitter":["Serrano Martinez P"],"funding":["Dutch Cancer Society","ZonMw"],"pubmed_abstract":["Stem/progenitor cells are required for maintenance of salivary gland (SG) function and serve as untapped reservoirs to create functional cells. Despite recent advancements in the identification of stem/progenitor pools, in the submandibular gland (SMG), a knowledge gap remains. Furthermore, the contribution to adult SMG homeostasis of stem/progenitor cells originating from embryonic development is unclear. Here, we employ an H2B-GFP embryonic and adult pulse-and-chase system to characterize potential SMG stem/progenitor cells (SGSCs) based on quiescence at different stages. Phenotypical profiling of quiescent cells in the SMG revealed that label-retaining cells (LRCs) of embryonic or adult origin co-localized with CK8+ ductal or vimentin + mesenchymal, but not with CK5+ or CK14 + stem/prog"],"journal":["iScience"],"pagination":["105047"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9485076"],"repository":["biostudies-literature"],"pubmed_title":["Role of quiescent cells in the homeostatic maintenance of the adult submandibular salivary gland."],"pmcid":["PMC9485076"],"pubmed_authors":["Maimets M","Serrano Martinez P","Pringle S","van Os R","de Haan G","Bron R","Coppes RP"],"additional_accession":[]},"is_claimable":false,"name":"Role of quiescent cells in the homeostatic maintenance of the adult submandibular salivary gland.","description":"Stem/progenitor cells are required for maintenance of salivary gland (SG) function and serve as untapped reservoirs to create functional cells. Despite recent advancements in the identification of stem/progenitor pools, in the submandibular gland (SMG), a knowledge gap remains. Furthermore, the contribution to adult SMG homeostasis of stem/progenitor cells originating from embryonic development is unclear. Here, we employ an H2B-GFP embryonic and adult pulse-and-chase system to characterize potential SMG stem/progenitor cells (SGSCs) based on quiescence at different stages. Phenotypical profiling of quiescent cells in the SMG revealed that label-retaining cells (LRCs) of embryonic or adult origin co-localized with CK8+ ductal or vimentin + mesenchymal, but not with CK5+ or CK14 + stem/prog","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-18T15:47:57.831Z","creation":"2025-02-19T01:37:55.453Z"},"accession":"S-EPMC9485076","cross_references":{"pubmed":["36147959"],"doi":["10.1016/j.isci.2022.105047"]}}