{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang Q"],"funding":["Square Foundation","Fondation Bettencourt-Schueller","Université Paris Cité","NCATS NIH HHS","Imagine Institute","CSL Behring Chair of Primary Immunodeficiencies","ANR GENVIR","French Ministry of Health","JPB Foundation","St. Giles Foundation","Instituto de Salud Carlos III","KU Leuven","Jeffrey Modell Foundation","European Union's Horizon 2020 research and innovation program","PIA ACT 1408","NIH HHS","Spanish Ministry for Science and Innovation","Center for Research on Influenza Pathogenesis and Transmission","Investments for the Future","ANR GenMISC","Junta de Andalucía","Sociedad Española de Neumología y Cirugía Torácica","Fonds Wetenschappelijk Onderzoek","ANRT CIFRE","Rockefeller University","European Regional Development Fund","French Foundation for Medical Research","Grupo DISA","Plan Nacional de I+D+i 2013-2016","Howard Hughes Medical Institute","French National Research Agency","ANR AABIFNCOV","SCOR Corporate Foundation for Science","Fondation du Souffle","Integrative Biology of Emerging Infectious Diseases Laboratory of Excellence","ANR-21-RHUS-08","Grandir-Fonds de solidarité pour l'enfance","Fisher Center for Alzheimer's Research Foundation","HORIZON-HLTH-2021-DISEASE-04","French Ministry of Higher Education, Research, and Innovation","Institut National de la Santé et de la Recherche Médicale","Agencia Nacional de Investigación y Desarrollo","Fundación MAPFRE Guanarteme","FONDECYT","National Institute of Allergy and Infectious Diseases","ANRS-COV05","FLUOMICS Consortium","Hellenic Foundation for Research and Innovation","Meyer Foundation","Cabildo Insular de Tenerife","Spanish Network for Research in Infectious Diseases","ANR-RHU"],"pagination":["e20220514"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9485705"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["219(11)"],"pubmed_abstract":["Autoantibodies neutralizing type I interferons (IFNs) can underlie critical COVID-19 pneumonia and yellow fever vaccine disease. We report here on 13 patients harboring autoantibodies neutralizing IFN-α2 alone (five patients) or with IFN-ω (eight patients) from a cohort of 279 patients (4.7%) aged 6-73 yr with critical influenza pneumonia. Nine and four patients had antibodies neutralizing high and low concentrations, respectively, of IFN-α2, and six and two patients had antibodies neutralizing high and low concentrations, respectively, of IFN-ω. The patients' autoantibodies increased influenza A virus replication in both A549 cells and reconstituted human airway epithelia. The prevalence of these antibodies was significantly higher than that in the general population for patients <70 yr o"],"journal":["The Journal of experimental medicine"],"pubmed_title":["Autoantibodies against type I IFNs in patients with critical influenza pneumonia."],"pmcid":["PMC9485705"],"funding_grant_id":["ANR-20-CO11-0001","COV20_01333","1161971","C16/18/007","P18-RT-3320","RTC-2017-6471-1","PHRC-I 2013 ANTIGRIPPE","EA20170638020","G0C8517N","ANR-20-CE93-003","CGIEU0000219140","U19AI135972","ANR-21-COVR-0039","R01AI088364","01057100","1574","REIPI RD16/0016/0009","ANR-10-LABX-62-IBEID","EQU201903007798","CB21/13/00006","ANR-10-IAHU-01","824110"],"pubmed_authors":["Froidure A","Sancho-Shimizu V","Dominguez-Pinilla N","Gervais A","Tzourio C","Rodriguez-Gallego C","Bastard P","Butte MJ","Wauters J","Rombauts A","Cognasse F","Darmon M","van de Beek D","Al-Muhsen S","Pape JW","Spaan AN","Husebye E","Miorin L","Pan-Hammarstrom Q","Le Got S","Rosain J","Abad Arranz M","Garcia-Sastre A","Ozcelik T","Karamitros T","Aiuti A","Romero Vazquez GM","REIPI INF Working Group","Meyts I","Heath JR","Uddin MJ","Fournet T","Sanchez-Cespedes J","Le Voyer T","Bolze A","Colomb B","Ferres M","Medina RA","Dufouil C","Retamar-Gentil P","Lei WT","Novelli A","Argaud L","Halwani R","Shahrooei M","Renia L","Brodin P","3C-Dijon Study","Garcia-Salum T","Mogensen TH","Soumare A","Sediva A","Pujol A","Boeuf B","Triantafyllia V","Milner JD","Del Mar Munoz Garcia M","Flores C","Vanderbeke L","Lau YL","Bousfiha AA","Trouillet-Assant S","Uddin KMF","Novelli G","Palomo V","Prando C","O'Farrelly C","Salamanca Rivera C","Valiente A","Tsiodras S","Castagnoli R","Aydillo T","Notarangelo LD","Abel L","Tiberghien P","Philippot Q","Bondarenko A","Constantinescu SN","Tancevski I","Navarrete N","Laurent E","Flaig A","Escoresca Ortega A","Bryceson Y","Perroquin M","Kuo CY","Ramirez Duque N","Cobat A","El Baghdadi J","Souweine B","Ku CL","Saker K","Casalegno JS","Tangye SG","Briones M","Baris Feldman H","Fievet N","Henny J","Arias AA","Hsieh EWY","Balsera-Manzanero M","Abelenda-Alonso G","Mironska K","Zawadzki P","Wroblewski I","Abou Tayoun A","Zhang Q","Zins M","COVID Human Genetic Effort","Martin F","Richard P","Ferreres J","Feys S","Espinosa-Padilla S","Morel P","Queromes G","Casari G","Fragkou PC","Galani IE","Biggs CM","Etzioni A","Lachaize M","Dalgard CL","Henrickson SE","Christodoulou J","Imai K","Marodi L","Shcherbina A","Tal G","Casanova JL","Bonneaudeau B","Condino-Neto A","Rodriguez de Castro F","Seppanen MRJ","Hernu R","Merino Diaz L","Ruiz-Hernandez JJ","Sole-Violan J","Desai M","Grimbacher B","Peigue-Lafeuille H","Rapti V","Hammarstrom L","Lemonnier S","Gallardo Rios R","Fellay J","Hagin D","Pothier P","Jouanguy E","Jeanne M","Al-Mulla F","Ling Y","Snow AL","Okamoto K","Lyon Antigrippe Working Group","Javouhey E","Franco JL","Bustamante CD","Vinh DC","Cordero E","Drolet BA","Belot A","Etablissement Français du Sang Study Group","Mansouri D","Koltsida O","Goavec K","Coeuret-Pellicer M","Haerynck F","Kisand K","Romero Oraa L","Sarekannu K","Aguilar Guisado M","Temel SG","Perez de Diego R","Puel A","Maniatis T","Hanna S","Resnick I","Lina B","Cupic A","Le Corre N","Ng LFP","Goldberg M","Su HC","Rosa-Calatrava M","Jarvis ED","Sallette J","Soler-Palacin P","Debette S","Pizzorno A","Pesole G","Mehlal-Sedkaoui S","Hamzeh-Cognasse H","Ozguler A","Sanchez Cordero MJ","Rovina N","Slaby O","von Bernuth H","Perlin DS","Turvey SE","Niubo J","Vanker M","Ramaswamy S","Bizien L","Carratala J","Andreakos E","Cerba HealthCare Group","Cannet D","Patural H","Schwebel C","Itan Y","Cooper MA","Zatz M","Anderson MS","Nadif R","Bogunovic D","Padey B","Manry J","Gallian P","Gregersen PK","Morio T","Planas AM","Lucas CL","Pozzetto B","Constances Cohort","Gonzalez-Granado LI","Morand P","Quenot JP","Okada S","Quintana-Murci L"],"additional_accession":[]},"is_claimable":false,"name":"Autoantibodies against type I IFNs in patients with critical influenza pneumonia.","description":"Autoantibodies neutralizing type I interferons (IFNs) can underlie critical COVID-19 pneumonia and yellow fever vaccine disease. We report here on 13 patients harboring autoantibodies neutralizing IFN-α2 alone (five patients) or with IFN-ω (eight patients) from a cohort of 279 patients (4.7%) aged 6-73 yr with critical influenza pneumonia. Nine and four patients had antibodies neutralizing high and low concentrations, respectively, of IFN-α2, and six and two patients had antibodies neutralizing high and low concentrations, respectively, of IFN-ω. The patients' autoantibodies increased influenza A virus replication in both A549 cells and reconstituted human airway epithelia. The prevalence of these antibodies was significantly higher than that in the general population for patients <70 yr o","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-04T20:19:55.519Z","creation":"2025-04-04T20:19:55.519Z"},"accession":"S-EPMC9485705","cross_references":{"pubmed":["36112363"],"doi":["10.1084/jem.20220514"]}}