biostudies-literatureLin CYChang Gung Memorial Hospital665-674https://www.ebi.ac.uk/biostudies/studies/S-EPMC9486242biostudies-literatureUnknown45(4)<h4>Background</h4>Sepsis-associated acute kidney injury (AKI) often worsens with the deterioration of a patient's condition. Therefore, we hypothesized that monitoring AKI dynamically from day 1 to day 3 was potential to predict hospital mortality. Specifically, we explored whether monitoring AKI dynamically in the intensive care unit (ICU) could be a sepsis phenotype predictive of mortality. A new classification was established based on the change in the AKI stage from admission day 1 and day 3. We compared the hospital mortality, cytokines, and immune response pattern between each group.<h4>Methods</h4>We retrospectively enrolled 523 patients with sepsis, and we calculated the AKI stages on day 1 and day 3 admission to ICUs. Among these 523 people, 388 of them were assigned to normal, iBiomedical journalDynamic monitoring of kidney injury status over 3 days in the intensive care unit as a sepsis phenotype associated with hospital mortality and hyperinflammation.PMC9486242CMRP8E0731CMRPG8J0421CMRPG8B1073CMRPG8B1063CMRPG8J0422CMRPG8H1171CMRPG8B1083Chen YCFang WFWang YHHung KYHuang KTLin CYChang YCLin MCFang YTChen HCChang YTChang HCWang CCChen YMfalseDynamic monitoring of kidney injury status over 3 days in the intensive care unit as a sepsis phenotype associated with hospital mortality and hyperinflammation.<h4>Background</h4>Sepsis-associated acute kidney injury (AKI) often worsens with the deterioration of a patient's condition. Therefore, we hypothesized that monitoring AKI dynamically from day 1 to day 3 was potential to predict hospital mortality. Specifically, we explored whether monitoring AKI dynamically in the intensive care unit (ICU) could be a sepsis phenotype predictive of mortality. A new classification was established based on the change in the AKI stage from admission day 1 and day 3. We compared the hospital mortality, cytokines, and immune response pattern between each group.<h4>Methods</h4>We retrospectively enrolled 523 patients with sepsis, and we calculated the AKI stages on day 1 and day 3 admission to ICUs. Among these 523 people, 388 of them were assigned to normal, i2022-01-01T00:00:00Z2022 Aug2025-04-18T20:57:04.701Z2025-04-07T08:56:16.498ZS-EPMC94862423448201510.1016/j.bj.2021.08.006