biostudies-literatureWang YNatural Science Foundation of Zhejiang ProvinceNational Natural Science Foundation of Chinae062096https://www.ebi.ac.uk/biostudies/studies/S-EPMC9486336biostudies-literatureUnknown12(9)<h4>Objectives</h4>To explore the outcomes of <i>Helicobacter pylori</i> infection treatments for naïve patients in the real-world settings.<h4>Design</h4>A retrospective observational study.<h4>Setting</h4>Single tertiary level academic hospital in China.<h4>Participants</h4>We identified patients initially receiving quadruple therapy for <i>H. pylori</i> infection from 2017 to 2020 in whom eradication was confirmed (n=23 470).<h4>Primary outcome</h4>Efficacy of different initial <i>H. pylori</i> infection treatments.<h4>Secondary outcome</h4>Results of urea breath test (UBT) after <i>H. pylori</i> eradication.<h4>Results</h4>Among 23 470 patients who received initial <i>H. pylori</i> treatment, 21 285 (90.7%) were treated with amoxicillin-based regimens. The median age of the patients deBMJ openShort-term outcomes and intermediate-term follow-up of <i>Helicobacter pylori</i> infection treatment for naive patients: a retrospective observational study.PMC9486336LY21H16002381773065Li YDu QXiang YWang YWu YLiao OYe JfalseShort-term outcomes and intermediate-term follow-up of <i>Helicobacter pylori</i> infection treatment for naive patients: a retrospective observational study.<h4>Objectives</h4>To explore the outcomes of <i>Helicobacter pylori</i> infection treatments for naïve patients in the real-world settings.<h4>Design</h4>A retrospective observational study.<h4>Setting</h4>Single tertiary level academic hospital in China.<h4>Participants</h4>We identified patients initially receiving quadruple therapy for <i>H. pylori</i> infection from 2017 to 2020 in whom eradication was confirmed (n=23 470).<h4>Primary outcome</h4>Efficacy of different initial <i>H. pylori</i> infection treatments.<h4>Secondary outcome</h4>Results of urea breath test (UBT) after <i>H. pylori</i> eradication.<h4>Results</h4>Among 23 470 patients who received initial <i>H. pylori</i> treatment, 21 285 (90.7%) were treated with amoxicillin-based regimens. The median age of the patients de2022-01-01T00:00:00Z2022 Sep2025-04-19T21:45:59.018Z2025-04-19T21:45:59.018ZS-EPMC94863363611567110.1136/bmjopen-2022-062096