biostudies-literatureUnknown12Wang C<h4>Purpose</h4>Previous studies have suggested a link between cardiovascular disease (CVD) and the subsequent development of lung cancer. However, empirical evidence on the association of CVDs, particularly type-specific CVDs, with lung cancer incidence and survival remains limited.<h4>Methods</h4>The cohort study included 306,285 patients with CVD and 1,222,140 individuals without CVD. We performed stratified Cox regression to estimate the hazard ratio (HR).<h4>Results</h4>During up to 42 years of follow-up, 243 (0.08%) and 537 (0.04%) participants were diagnosed with lung cancer among CVD patients and matched individuals, respectively. Patients with CVD had a 67% increased risk of lung cancer (HR: 1.67, 95% confidence interval [CI]: 1.42-1.96). The increased risks were observed in patieFrontiers in oncology950971https://www.ebi.ac.uk/biostudies/studies/S-EPMC9486704biostudies-literatureCardiovascular disease and risk of lung cancer incidence and mortality: A nationwide matched cohort study.PMC9486704Huang CLi JWang CWei DLu DQin GCronin-Fenton DLiew ZYu YfalseCardiovascular disease and risk of lung cancer incidence and mortality: A nationwide matched cohort study.<h4>Purpose</h4>Previous studies have suggested a link between cardiovascular disease (CVD) and the subsequent development of lung cancer. However, empirical evidence on the association of CVDs, particularly type-specific CVDs, with lung cancer incidence and survival remains limited.<h4>Methods</h4>The cohort study included 306,285 patients with CVD and 1,222,140 individuals without CVD. We performed stratified Cox regression to estimate the hazard ratio (HR).<h4>Results</h4>During up to 42 years of follow-up, 243 (0.08%) and 537 (0.04%) participants were diagnosed with lung cancer among CVD patients and matched individuals, respectively. Patients with CVD had a 67% increased risk of lung cancer (HR: 1.67, 95% confidence interval [CI]: 1.42-1.96). The increased risks were observed in patie2022-01-01T00:00:00Z20222025-04-19T21:43:12.443Z2025-04-19T21:43:12.443ZS-EPMC94867043614790910.3389/fonc.2022.950971