biostudies-literatureUnknown81Khan QA<h4>Background</h4>Non-Hodgkin's lymphoma (NHL) is a monoclonal proliferation of lymphoid cells from B lineage. Although NHLs are primarily hematological tumors of lymph nodes but rarely can involve extranodal sites such as the spleen.<h4>Case report</h4>A 29-year-old female patient presented with low-grade fever, cough, anemia, weight loss, tender left hypochondrium, and splenomegaly. A hypodense lesion in the spleen with central necrosis, having strong positivity for common leukocyte antigen (LCA), CD 20, and CD 10, led to a diffuse large B cell lymphoma diagnosis. The patient had an excellent clinical post-splenectomy response to combination chemotherapy and immunotherapy.<h4>Conclusion</h4>NHL can present with symptomatic extra-nodal involvement without enlarged lymph nodes.Annals of medicine and surgery (2012)104449https://www.ebi.ac.uk/biostudies/studies/S-EPMC9486706biostudies-literatureNon-Hodgkin's lymphoma masquerading as splenic abscess: A case report.PMC9486706Mahfooz RSKhan QAAin HUBaqi AHussien Mohamed Ahmed KAAsim NYousaf ZTahir MJMumtaz AIram SfalseNon-Hodgkin's lymphoma masquerading as splenic abscess: A case report.<h4>Background</h4>Non-Hodgkin's lymphoma (NHL) is a monoclonal proliferation of lymphoid cells from B lineage. Although NHLs are primarily hematological tumors of lymph nodes but rarely can involve extranodal sites such as the spleen.<h4>Case report</h4>A 29-year-old female patient presented with low-grade fever, cough, anemia, weight loss, tender left hypochondrium, and splenomegaly. A hypodense lesion in the spleen with central necrosis, having strong positivity for common leukocyte antigen (LCA), CD 20, and CD 10, led to a diffuse large B cell lymphoma diagnosis. The patient had an excellent clinical post-splenectomy response to combination chemotherapy and immunotherapy.<h4>Conclusion</h4>NHL can present with symptomatic extra-nodal involvement without enlarged lymph nodes.2022-01-01T00:00:00Z2022 Sep2025-04-25T19:13:47.477Z2025-04-06T07:51:23.129ZS-EPMC94867063614711110.1016/j.amsu.2022.104449