biostudies-literatureLee DSEngineering and Physical Sciences Research Council2674-2684https://www.ebi.ac.uk/biostudies/studies/S-EPMC9486933biostudies-literatureUnknown26(9)We report the development of a <i>single-pass</i> electrochemical Birch reduction carried out in a small footprint electrochemical Taylor vortex reactor with projected productivities of >80 g day^-1 (based on 32.2 mmol h^-1), using a modified version of our previously reported reactor [<i>Org. Process Res. Dev.</i> <b>2021</b>, <i>25</i>, 7, 1619-1627], consisting of a static outer electrode and a rapidly rotating cylindrical inner electrode. In this study, we used an aluminum tube as the sacrificial outer electrode and stainless steel as the rotating inner electrode. We have established the viability of using a sacrificial aluminum anode for the electrochemical reduction of naphthalene, and by varying the current, we can switch between high selectivity (>90%) for eitheOrganic process research & developmentHigh-Productivity Single-Pass Electrochemical Birch Reduction of Naphthalenes in a Continuous Flow Electrochemical Taylor Vortex Reactor.PMC9486933EP/P013341/1Love AHarrowven DCJefferson-Loveday RMansouri ZPickering SJWaldron Clarke THGeorge MWLee DSPoliakoff MfalseHigh-Productivity Single-Pass Electrochemical Birch Reduction of Naphthalenes in a Continuous Flow Electrochemical Taylor Vortex Reactor.We report the development of a <i>single-pass</i> electrochemical Birch reduction carried out in a small footprint electrochemical Taylor vortex reactor with projected productivities of >80 g day^-1 (based on 32.2 mmol h^-1), using a modified version of our previously reported reactor [<i>Org. Process Res. Dev.</i> <b>2021</b>, <i>25</i>, 7, 1619-1627], consisting of a static outer electrode and a rapidly rotating cylindrical inner electrode. In this study, we used an aluminum tube as the sacrificial outer electrode and stainless steel as the rotating inner electrode. We have established the viability of using a sacrificial aluminum anode for the electrochemical reduction of naphthalene, and by varying the current, we can switch between high selectivity (>90%) for eithe2022-01-01T00:00:00Z2022 Sep2025-04-20T00:39:23.439Z2025-04-20T00:39:23.439ZS-EPMC94869333615846710.1021/acs.oprd.2c00108