biostudies-literatureUnknown24(136)Exley DAdverse childhood experiences such as abuse and neglect are associated with subsequent immune dysregulation. Some studies show an association between adverse childhood experiences and asthma onset, although significant disparity in results exists in the published literature. We aimed to review available studies employing a prospective design that investigates associations between adverse childhood experience and asthma. A search protocol was developed and studies were drawn from four electronic journal databases. Studies were selected in accordance with pre-set inclusion criteria and relevant data were extracted. 12 studies, assessing data from a total of 31 524 individuals, were identified that investigate the impact of a range of adverse childhood experiences on the likelihood of developEuropean respiratory review : an official journal of the European Respiratory Society299-305https://www.ebi.ac.uk/biostudies/studies/S-EPMC9487809biostudies-literatureAdverse childhood experience and asthma onset: a systematic review.PMC9487809Exley DHyland MNorman AfalseAdverse childhood experience and asthma onset: a systematic review.Adverse childhood experiences such as abuse and neglect are associated with subsequent immune dysregulation. Some studies show an association between adverse childhood experiences and asthma onset, although significant disparity in results exists in the published literature. We aimed to review available studies employing a prospective design that investigates associations between adverse childhood experience and asthma. A search protocol was developed and studies were drawn from four electronic journal databases. Studies were selected in accordance with pre-set inclusion criteria and relevant data were extracted. 12 studies, assessing data from a total of 31 524 individuals, were identified that investigate the impact of a range of adverse childhood experiences on the likelihood of develop2015-01-01T00:00:00Z2015 Jun2025-04-18T19:07:42.26Z2025-04-07T06:47:59.478ZS-EPMC94878092602864110.1183/16000617.00004114