biostudies-literatureUnknown17(9)Dai LSMARCA1is a mammalian imitation switch (ISWI) gene that encodes for SNF2L. SNF2L is involved in regulating cell transition from a committed progenitor state to a differentiated state. Although many papers have detailed the correlation between SMARCA1 and different cancers, no pan-cancer analysis has been conducted to date. We started by exploring the potential carcinogenic role of SMARCA1 across 33 carcinomas using the cancer genome atlas (TCGA) and the genotype-tissue expression (GTEx) databases. The expression of SMARCA1 was significantly elevated in some tumor types but not in others. There was a distinct relationship between SMARCA1 expression and patient prognosis. S116 phosphorylation levels were up-regulated in both lung adenocarcinoma and uterine corpus endometrial carcinoma. The ePloS onee0274823https://www.ebi.ac.uk/biostudies/studies/S-EPMC9488775biostudies-literatureA pan-cancer bioinformatic analysis of the carcinogenic role of SMARCA1 in human carcinomas.PMC9488775Dai LZhang TTong JLu CMugaanyi JCai XfalseA pan-cancer bioinformatic analysis of the carcinogenic role of SMARCA1 in human carcinomas.SMARCA1is a mammalian imitation switch (ISWI) gene that encodes for SNF2L. SNF2L is involved in regulating cell transition from a committed progenitor state to a differentiated state. Although many papers have detailed the correlation between SMARCA1 and different cancers, no pan-cancer analysis has been conducted to date. We started by exploring the potential carcinogenic role of SMARCA1 across 33 carcinomas using the cancer genome atlas (TCGA) and the genotype-tissue expression (GTEx) databases. The expression of SMARCA1 was significantly elevated in some tumor types but not in others. There was a distinct relationship between SMARCA1 expression and patient prognosis. S116 phosphorylation levels were up-regulated in both lung adenocarcinoma and uterine corpus endometrial carcinoma. The e2022-01-01T00:00:00Z20222025-04-18T15:48:13.456Z2024-11-09T18:20:40.645ZS-EPMC94887753612608310.1371/journal.pone.0274823