{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Antoni AC"],"funding":["Deutsche Forschungsgemeinschaft"],"pubmed_abstract":["Sepsis is associated with profound immune dysregulation that increases the risk for life-threatening secondary infections: Dendritic cells (DCs) undergo functional reprogramming due to yet unknown changes during differentiation in the bone marrow (BM). In parallel, lymphopenia and exhaustion of T lymphocytes interfere with antigen-specific adaptive immunity. We hypothesized that there exists a link between T cells and the modulation of DC differentiation in the BM during murine polymicrobial sepsis. Sepsis was induced by cecal ligation and puncture (CLP), a model for human bacterial sepsis. At different time points after CLP, the BM and spleen were analyzed in terms of T-cell subpopulations, activation, and Interferon (IFN)-γ synthesis as well as the number of pre-DCs. BM-derived DCs were "],"journal":["Frontiers in immunology"],"pagination":["945409"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9488929"],"repository":["biostudies-literature"],"pubmed_title":["TLR2-induced CD8<sup>+</sup> T-cell deactivation shapes dendritic cell differentiation in the bone marrow during sepsis."],"pmcid":["PMC9488929"],"pubmed_authors":["Klein-Hitpaß L","Antoni AC","Jablonska J","Dudda M","Budeus B","Pylaeva E","Flohe SB"],"additional_accession":[]},"is_claimable":false,"name":"TLR2-induced CD8<sup>+</sup> T-cell deactivation shapes dendritic cell differentiation in the bone marrow during sepsis.","description":"Sepsis is associated with profound immune dysregulation that increases the risk for life-threatening secondary infections: Dendritic cells (DCs) undergo functional reprogramming due to yet unknown changes during differentiation in the bone marrow (BM). In parallel, lymphopenia and exhaustion of T lymphocytes interfere with antigen-specific adaptive immunity. We hypothesized that there exists a link between T cells and the modulation of DC differentiation in the BM during murine polymicrobial sepsis. Sepsis was induced by cecal ligation and puncture (CLP), a model for human bacterial sepsis. At different time points after CLP, the BM and spleen were analyzed in terms of T-cell subpopulations, activation, and Interferon (IFN)-γ synthesis as well as the number of pre-DCs. BM-derived DCs were ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-28T04:23:25.534Z","creation":"2025-04-07T02:17:36.829Z"},"accession":"S-EPMC9488929","cross_references":{"pubmed":["36148245"],"doi":["10.3389/fimmu.2022.945409"]}}