{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ganassi M"],"funding":["Medical Research Council"],"pagination":["802573"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9490378"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10"],"pubmed_abstract":["Aberrant expression of the transcription factor DUX4 from D4Z4 macrosatellite repeats on chromosome 4q35, and its transcriptome, associate with pathogenesis in facioscapulohumeral muscular dystrophy (FSHD). Forced DUX4 expression halts skeletal muscle cell proliferation and induces cell death. DUX4 binds DNA via two homeodomains that are identical in sequence to those of DUX4c (DUX4L9): a closely related transcriptional regulator encoded by a single, inverted, mutated D4Z4 unit located centromeric to the D4Z4 macrosatellite array on chromosome 4. However, the function and contribution of DUX4c to FSHD pathogenesis are unclear. To explore interplay between DUX4, DUX4c, and the DUX4-induced phenotype, we investigated whether DUX4c interferes with DUX4 function in human myogenesis. Constituti"],"journal":["Frontiers in cell and developmental biology"],"pubmed_title":["Antagonism Between DUX4 and DUX4c Highlights a Pathomechanism Operating Through β-Catenin in Facioscapulohumeral Muscular Dystrophy."],"pmcid":["PMC9490378"],"funding_grant_id":["MR/S002472/1"],"pubmed_authors":["Figeac N","Ortuste Quiroga HP","Ganassi M","Reynaud M","Zammit PS"],"additional_accession":[]},"is_claimable":false,"name":"Antagonism Between DUX4 and DUX4c Highlights a Pathomechanism Operating Through β-Catenin in Facioscapulohumeral Muscular Dystrophy.","description":"Aberrant expression of the transcription factor DUX4 from D4Z4 macrosatellite repeats on chromosome 4q35, and its transcriptome, associate with pathogenesis in facioscapulohumeral muscular dystrophy (FSHD). Forced DUX4 expression halts skeletal muscle cell proliferation and induces cell death. DUX4 binds DNA via two homeodomains that are identical in sequence to those of DUX4c (DUX4L9): a closely related transcriptional regulator encoded by a single, inverted, mutated D4Z4 unit located centromeric to the D4Z4 macrosatellite array on chromosome 4. However, the function and contribution of DUX4c to FSHD pathogenesis are unclear. To explore interplay between DUX4, DUX4c, and the DUX4-induced phenotype, we investigated whether DUX4c interferes with DUX4 function in human myogenesis. Constituti","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-06-20T03:25:00.476Z","creation":"2025-02-19T04:38:49.106Z"},"accession":"S-EPMC9490378","cross_references":{"pubmed":["36158201"],"doi":["10.3389/fcell.2022.802573"]}}