biostudies-literatureUnknownEgger JRCountries in the Greater Mekong Subregion have committed to eliminate Plasmodium falciparum malaria by 2025. Subclinical malaria infections that can be detected by highly sensitive polymerase chain reaction (PCR) testing in asymptomatic individuals represent a potential impediment to this goal, although the extent to which these low-density infections contribute to transmission is unclear. To understand the temporal dynamics of subclinical malaria in this setting, a cohort of 2,705 participants from three epidemiologically distinct regions of Myanmar was screened for subclinical P. falciparum and P. vivax infection using ultrasensitive PCR (usPCR). Standard rapid diagnostic tests (RDTs) for P. falciparum were also performed. Individuals who tested positive for malaria by usPCR were followeThe American journal of tropical medicine and hygienetpmd220027https://www.ebi.ac.uk/biostudies/studies/S-EPMC9490656biostudies-literatureTemporal Dynamics of Subclinical Malaria in Different Transmission Zones of Myanmar.PMC9490656Fang HThi ANyunt MMAung PPHan ZYPlatt AMarkwalter CFThant MEgger JRHlaing TMHan KTSimmons RHtay THogue JOo SMPlowe CVZhou XNHong TMeng MThein ZWWang XXTun ZMPaing AKThane TKfalseTemporal Dynamics of Subclinical Malaria in Different Transmission Zones of Myanmar.Countries in the Greater Mekong Subregion have committed to eliminate Plasmodium falciparum malaria by 2025. Subclinical malaria infections that can be detected by highly sensitive polymerase chain reaction (PCR) testing in asymptomatic individuals represent a potential impediment to this goal, although the extent to which these low-density infections contribute to transmission is unclear. To understand the temporal dynamics of subclinical malaria in this setting, a cohort of 2,705 participants from three epidemiologically distinct regions of Myanmar was screened for subclinical P. falciparum and P. vivax infection using ultrasensitive PCR (usPCR). Standard rapid diagnostic tests (RDTs) for P. falciparum were also performed. Individuals who tested positive for malaria by usPCR were followe2022-01-01T00:00:00Z2022 Jul2025-04-04T20:19:46.879Z2025-04-04T20:19:46.879ZS-EPMC94906563589534110.4269/ajtmh.22-0027