{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(41)"],"submitter":["Han Z"],"pubmed_abstract":["An efficient organocatalytic conjugated addition reaction of pyrazol-3-ones with 3-trifluoroethylidene oxindoles has been developed for the synthesis of enantioenriched triflouromethylated indolin-2-ones bearing adjacent tertiary chiral centers in good yields and good to excellent diastereo- and enantioselectivities. The use of a newly developed chiral spirobiindane-derived squaramide catalyst is essential in achieving high diastereo- and enantioselectivities."],"journal":["RSC advances"],"pagination":["27012-27021"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9490773"],"repository":["biostudies-literature"],"pubmed_title":["Organocatalytic diastereo- and enantioselective conjugate addition of pyrazol-3-ones to 3-trifluoroethylidene oxindoles with a newly developed squaramide catalyst."],"pmcid":["PMC9490773"],"pubmed_authors":["Woldegiorgis AG","Lin X","Han Z","Jin J"],"additional_accession":[]},"is_claimable":false,"name":"Organocatalytic diastereo- and enantioselective conjugate addition of pyrazol-3-ones to 3-trifluoroethylidene oxindoles with a newly developed squaramide catalyst.","description":"An efficient organocatalytic conjugated addition reaction of pyrazol-3-ones with 3-trifluoroethylidene oxindoles has been developed for the synthesis of enantioenriched triflouromethylated indolin-2-ones bearing adjacent tertiary chiral centers in good yields and good to excellent diastereo- and enantioselectivities. The use of a newly developed chiral spirobiindane-derived squaramide catalyst is essential in achieving high diastereo- and enantioselectivities.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-05T13:27:45.613Z","creation":"2025-04-05T13:27:45.613Z"},"accession":"S-EPMC9490773","cross_references":{"pubmed":["36320851"],"doi":["10.1039/d2ra05088a"]}}