{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(41)"],"submitter":["Fang Z"],"pubmed_abstract":["The synthesis of γ-lactam-substituted quinone derivatives through a Ag<sub>2</sub>O-catalyzed cascade cyclization and functionalization of <i>N</i>-aryl-4-pentenamides has been developed. Related 2-oxazolidinone substituted quinone products can be also obtained with <i>N</i>-aryl allyl carbamates. The reactions proceed through an amidyl radical-initiated 5-<i>exo</i>-trig cyclization and followed radical addition to quinones. They provide an efficient route to various γ-lactam-substituted quinone derivatives with a wide range of substrate scope."],"journal":["RSC advances"],"pagination":["26776-26780"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9490777"],"repository":["biostudies-literature"],"pubmed_title":["Silver-catalyzed cascade cyclization and functionalization of <i>N</i>-aryl-4-pentenamides: an efficient route to γ-lactam-substituted quinone derivatives."],"pmcid":["PMC9490777"],"pubmed_authors":["Fang Z","Li D","Xie L","Zhang Q","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"Silver-catalyzed cascade cyclization and functionalization of <i>N</i>-aryl-4-pentenamides: an efficient route to γ-lactam-substituted quinone derivatives.","description":"The synthesis of γ-lactam-substituted quinone derivatives through a Ag<sub>2</sub>O-catalyzed cascade cyclization and functionalization of <i>N</i>-aryl-4-pentenamides has been developed. Related 2-oxazolidinone substituted quinone products can be also obtained with <i>N</i>-aryl allyl carbamates. The reactions proceed through an amidyl radical-initiated 5-<i>exo</i>-trig cyclization and followed radical addition to quinones. They provide an efficient route to various γ-lactam-substituted quinone derivatives with a wide range of substrate scope.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-05T13:27:47.655Z","creation":"2025-04-05T13:27:47.655Z"},"accession":"S-EPMC9490777","cross_references":{"pubmed":["36320855"],"doi":["10.1039/d2ra05283k"]}}