biostudies-literatureUnknown12(41)Fang ZThe synthesis of γ-lactam-substituted quinone derivatives through a Ag₂O-catalyzed cascade cyclization and functionalization of <i>N</i>-aryl-4-pentenamides has been developed. Related 2-oxazolidinone substituted quinone products can be also obtained with <i>N</i>-aryl allyl carbamates. The reactions proceed through an amidyl radical-initiated 5-<i>exo</i>-trig cyclization and followed radical addition to quinones. They provide an efficient route to various γ-lactam-substituted quinone derivatives with a wide range of substrate scope.RSC advances26776-26780https://www.ebi.ac.uk/biostudies/studies/S-EPMC9490777biostudies-literatureSilver-catalyzed cascade cyclization and functionalization of <i>N</i>-aryl-4-pentenamides: an efficient route to γ-lactam-substituted quinone derivatives.PMC9490777Fang ZLi DXie LZhang QWang LfalseSilver-catalyzed cascade cyclization and functionalization of <i>N</i>-aryl-4-pentenamides: an efficient route to γ-lactam-substituted quinone derivatives.The synthesis of γ-lactam-substituted quinone derivatives through a Ag₂O-catalyzed cascade cyclization and functionalization of <i>N</i>-aryl-4-pentenamides has been developed. Related 2-oxazolidinone substituted quinone products can be also obtained with <i>N</i>-aryl allyl carbamates. The reactions proceed through an amidyl radical-initiated 5-<i>exo</i>-trig cyclization and followed radical addition to quinones. They provide an efficient route to various γ-lactam-substituted quinone derivatives with a wide range of substrate scope.2022-01-01T00:00:00Z2022 Sep2025-04-05T13:27:47.655Z2025-04-05T13:27:47.655ZS-EPMC94907773632085510.1039/d2ra05283k