biostudies-literatureUnknown12(41)Jiang YIn this study, new magnetic nanoparticles (denotated as Fe₃O₄@mSiO₂-PFIL-Ti⁴⁺) have been prepared by immobilizing titanium ions with phosphonate functionalized ionic liquid (PFIL) on the wall of core-shell structured mesoporous nanomaterials. The resulting nanoparticles possess large specific surface area, strong hydrophilicity and fast magnetic response. The composites can capture traces of phosphopeptides from the tryptic β-casein digest (0.08 fmol), a digest mixture of β-casein and BSA (1 : 10 000, molar ratio) as well as a blend of β-casein digest and a great quantity of phosphorylated protein (β-casein) and non-phosphorylated protein (BSA) (1 : 2000 : 2000, mass ratio), respectively, showing excellent sensitivity, selectivity and size exclusRSC advances26859-26865https://www.ebi.ac.uk/biostudies/studies/S-EPMC9490807biostudies-literatureMagnetic mesoporous silica nanoparticles modified by phosphonate functionalized ionic liquid for selective enrichment of phosphopeptides.PMC9490807Jiang YZhao LLiang WWang QWang BLiang HCui WXia CYan YFeng QfalseMagnetic mesoporous silica nanoparticles modified by phosphonate functionalized ionic liquid for selective enrichment of phosphopeptides.In this study, new magnetic nanoparticles (denotated as Fe₃O₄@mSiO₂-PFIL-Ti⁴⁺) have been prepared by immobilizing titanium ions with phosphonate functionalized ionic liquid (PFIL) on the wall of core-shell structured mesoporous nanomaterials. The resulting nanoparticles possess large specific surface area, strong hydrophilicity and fast magnetic response. The composites can capture traces of phosphopeptides from the tryptic β-casein digest (0.08 fmol), a digest mixture of β-casein and BSA (1 : 10 000, molar ratio) as well as a blend of β-casein digest and a great quantity of phosphorylated protein (β-casein) and non-phosphorylated protein (BSA) (1 : 2000 : 2000, mass ratio), respectively, showing excellent sensitivity, selectivity and size exclus2022-01-01T00:00:00Z2022 Sep2025-04-05T13:27:50.52Z2025-04-05T13:27:50.52ZS-EPMC94908073632085810.1039/d2ra04609a