biostudies-literatureUnknown24(24)Franco FMinistero dell&apos;Universit? e della RicercaEuropean CommissionUniversit? degli Studi di SalernoA highly enantioselective one-pot synthesis of functionalized triflones, bearing a quaternary stereocenter, has been developed, exploiting the Michael reaction of α-(trifluoromethylsulfonyl) aryl acetic acid esters with <i>N</i>-acryloyl-1<i>H</i>-pyrazole catalyzed by commercially available Takemoto's catalyst, followed by nucleophilic acyl substitution with alcohols. Preliminary investigations highlighted the attractive potential of the triflinate anion as the leaving group for stereocontrolled postfunctionalizations.Organic letters4371-4376https://www.ebi.ac.uk/biostudies/studies/S-EPMC9490835biostudies-literatureCatalytic Enantioselective Entry to Triflones Featuring a Quaternary Stereocenter.PMC9490835Franco FBenaglia MLattanzi AMeninno SOvergaard JRossi SfalseCatalytic Enantioselective Entry to Triflones Featuring a Quaternary Stereocenter.A highly enantioselective one-pot synthesis of functionalized triflones, bearing a quaternary stereocenter, has been developed, exploiting the Michael reaction of α-(trifluoromethylsulfonyl) aryl acetic acid esters with <i>N</i>-acryloyl-1<i>H</i>-pyrazole catalyzed by commercially available Takemoto's catalyst, followed by nucleophilic acyl substitution with alcohols. Preliminary investigations highlighted the attractive potential of the triflinate anion as the leaving group for stereocontrolled postfunctionalizations.2022-01-01T00:00:00Z2022 Jun2025-04-22T10:57:20.273Z2025-04-05T23:49:54.851ZS-EPMC94908353568751510.1021/acs.orglett.2c01589