biostudies-literatureWei SNational Natural Science Foundation of China150https://www.ebi.ac.uk/biostudies/studies/S-EPMC9490904biostudies-literatureUnknown20(1)Anti-epidermal-growth-factor-receptor (EGFR) monoclonal antibodies (mAbs) are of great significance for RAS and BRAF wild-type metastatic colorectal cancer (mCRC) patients. However, the generation of primary and secondary resistance to anti-EGFR mAbs has become an important factor restricting its efficacy. Recent studies have revealed that non-coding RNAs (ncRNAs), especially long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), are implicated in anti-EGFR antibodies resistance, affecting the sensitivity of CRC cells to Cetuximab and Panitumumab. This paper briefly reviewed the research advance of the expression, signaling network and functional mechanism of ncRNAs related to anti-EGFR mAbs resistance in CRC, as well as their relationship with clinical prognosisCell communication and signaling : CCSPromotion or remission: a role of noncoding RNAs in colorectal cancer resistance to anti-EGFR therapy.PMC949090482002479Feng JHu WWei SGeng YfalsePromotion or remission: a role of noncoding RNAs in colorectal cancer resistance to anti-EGFR therapy.Anti-epidermal-growth-factor-receptor (EGFR) monoclonal antibodies (mAbs) are of great significance for RAS and BRAF wild-type metastatic colorectal cancer (mCRC) patients. However, the generation of primary and secondary resistance to anti-EGFR mAbs has become an important factor restricting its efficacy. Recent studies have revealed that non-coding RNAs (ncRNAs), especially long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), are implicated in anti-EGFR antibodies resistance, affecting the sensitivity of CRC cells to Cetuximab and Panitumumab. This paper briefly reviewed the research advance of the expression, signaling network and functional mechanism of ncRNAs related to anti-EGFR mAbs resistance in CRC, as well as their relationship with clinical prognosis2022-01-01T00:00:00Z2022 Sep2026-06-21T03:22:56.205Z2026-06-21T03:13:12.951ZS-EPMC94909043613128110.1186/s12964-022-00960-x