{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Santos R"],"funding":["Swiss National Science Foundation"],"pagination":["206"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9490929"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(1)"],"pubmed_abstract":["<h4>Background</h4>Giardia lamblia, a parasitic protist of the Metamonada supergroup, has evolved one of the most diverged endocytic compartment systems investigated so far. Peripheral endocytic compartments, currently known as peripheral vesicles or vacuoles (PVs), perform bulk uptake of fluid phase material which is then digested and sorted either to the cell cytosol or back to the extracellular space.<h4>Results</h4>Here, we present a quantitative morphological characterization of these organelles using volumetric electron microscopy and super-resolution microscopy (SRM). We defined a morphological classification for the heterogenous population of PVs and performed a comparative analysis of PVs and endosome-like organelles in representatives of phylogenetically related taxa, Spironucleu"],"journal":["BMC biology"],"pubmed_title":["Combined nanometric and phylogenetic analysis of unique endocytic compartments in Giardia lamblia sheds light on the evolution of endocytosis in Metamonada."],"pmcid":["PMC9490929"],"funding_grant_id":["31003A-166437","PR00P3_179813"],"pubmed_authors":["Santos R","Hehl AB","Pipaliya SV","Astvaldsson A","Faso C","Zumthor JP","Dacks JB","Svard S"],"additional_accession":[]},"is_claimable":false,"name":"Combined nanometric and phylogenetic analysis of unique endocytic compartments in Giardia lamblia sheds light on the evolution of endocytosis in Metamonada.","description":"<h4>Background</h4>Giardia lamblia, a parasitic protist of the Metamonada supergroup, has evolved one of the most diverged endocytic compartment systems investigated so far. Peripheral endocytic compartments, currently known as peripheral vesicles or vacuoles (PVs), perform bulk uptake of fluid phase material which is then digested and sorted either to the cell cytosol or back to the extracellular space.<h4>Results</h4>Here, we present a quantitative morphological characterization of these organelles using volumetric electron microscopy and super-resolution microscopy (SRM). We defined a morphological classification for the heterogenous population of PVs and performed a comparative analysis of PVs and endosome-like organelles in representatives of phylogenetically related taxa, Spironucleu","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-19T09:50:19.414Z","creation":"2025-02-19T04:38:20.584Z"},"accession":"S-EPMC9490929","cross_references":{"pubmed":["36127707"],"doi":["10.1186/s12915-022-01402-3"]}}