biostudies-literatureOliveira JINConselho Nacional de Desenvolvimento Científico e TecnológicoFundação de Amparo à Pesquisa do Estado de São Paulo204https://www.ebi.ac.uk/biostudies/studies/S-EPMC9490952biostudies-literatureUnknown20(1)<h4>Background</h4>B chromosomes are extra elements found in several eukaryote species. Usually, they do not express a phenotype in the host. However, advances in bioinformatics over the last decades have allowed us to describe several genes and molecular functions related to B chromosomes. These advances enable investigations of the relationship between the B chromosome and the host to understand how this element has been preserved in genomes. However, considering that transposable elements (TEs) are highly abundant in this supernumerary chromosome, there is a lack of knowledge concerning the dynamics of TE control in B-carrying cells. Thus, the present study characterized PIWI-interacting RNA (piRNA) clusters and pathways responsible for silencing the mobilization of TEs in gonads of theBMC biologyFirst characterization of PIWI-interacting RNA clusters in a cichlid fish with a B chromosome.PMC9490952304111/2020-12016/09320-62015/16661-1Oliveira JINMartins Cde Oliveira RACardoso ALWolf IRfalseFirst characterization of PIWI-interacting RNA clusters in a cichlid fish with a B chromosome.<h4>Background</h4>B chromosomes are extra elements found in several eukaryote species. Usually, they do not express a phenotype in the host. However, advances in bioinformatics over the last decades have allowed us to describe several genes and molecular functions related to B chromosomes. These advances enable investigations of the relationship between the B chromosome and the host to understand how this element has been preserved in genomes. However, considering that transposable elements (TEs) are highly abundant in this supernumerary chromosome, there is a lack of knowledge concerning the dynamics of TE control in B-carrying cells. Thus, the present study characterized PIWI-interacting RNA (piRNA) clusters and pathways responsible for silencing the mobilization of TEs in gonads of the2022-01-01T00:00:00Z2022 Sep2026-07-14T16:00:25.741Z2025-02-19T04:38:58.104ZS-EPMC94909523612767910.1186/s12915-022-01403-2