{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7"],"submitter":["Saha AK"],"pubmed_abstract":["<h4>Background</h4>Corticosteroid dosing in COVID-19 cases associated with early-onset and late-onset hypoxia have not been separately explored.<h4>Methods</h4>In this retrospective cohort study, we divided hypoxic COVID-19 cases into groups based on timing of initiation of corticosteroids relative to onset of symptoms; Group A (≤6th day), Group B (7th-9th day) and Group C (≥10th day), each group being sub-grouped into high and low-to-moderate dose corticosteroid recipients. Cox regression with propensity scoring was used to compare 28-day mortality between high and low-to-moderate dose recipients separately in Group A, Group B, Group C.<h4>Results</h4>Among 505 patients included, propensity score matched Cox regression showed greater risk of all-cause mortality among high dose recipients "],"journal":["IJID regions"],"pagination":["31-42"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9492392"],"repository":["biostudies-literature"],"pubmed_title":["Treatment Outcome with High versus low-to-moderate Dosing of Corticosteroids in Early vis-a-vis Late-onset Hypoxic Cases of COVID-19: A Multicentric Retrospective Cohort Study."],"pmcid":["PMC9492392"],"pubmed_authors":["Ghosh D","Biswas S","Das S","Gowsami DN","Mukherjee A","Kumar S","Mitra M","Saha AK","Biswas D","Basu S","Shamim S","Chakraborty R","Todi SK","Sain B"],"additional_accession":[]},"is_claimable":false,"name":"Treatment Outcome with High versus low-to-moderate Dosing of Corticosteroids in Early vis-a-vis Late-onset Hypoxic Cases of COVID-19: A Multicentric Retrospective Cohort Study.","description":"<h4>Background</h4>Corticosteroid dosing in COVID-19 cases associated with early-onset and late-onset hypoxia have not been separately explored.<h4>Methods</h4>In this retrospective cohort study, we divided hypoxic COVID-19 cases into groups based on timing of initiation of corticosteroids relative to onset of symptoms; Group A (≤6th day), Group B (7th-9th day) and Group C (≥10th day), each group being sub-grouped into high and low-to-moderate dose corticosteroid recipients. Cox regression with propensity scoring was used to compare 28-day mortality between high and low-to-moderate dose recipients separately in Group A, Group B, Group C.<h4>Results</h4>Among 505 patients included, propensity score matched Cox regression showed greater risk of all-cause mortality among high dose recipients ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2025-04-03T21:30:36.564Z","creation":"2025-04-03T21:30:36.564Z"},"accession":"S-EPMC9492392","cross_references":{"pubmed":["36164344"],"doi":["10.1016/j.ijregi.2022.09.007"]}}