biostudies-literatureUnknown7Saha AK<h4>Background</h4>Corticosteroid dosing in COVID-19 cases associated with early-onset and late-onset hypoxia have not been separately explored.<h4>Methods</h4>In this retrospective cohort study, we divided hypoxic COVID-19 cases into groups based on timing of initiation of corticosteroids relative to onset of symptoms; Group A (≤6th day), Group B (7th-9th day) and Group C (≥10th day), each group being sub-grouped into high and low-to-moderate dose corticosteroid recipients. Cox regression with propensity scoring was used to compare 28-day mortality between high and low-to-moderate dose recipients separately in Group A, Group B, Group C.<h4>Results</h4>Among 505 patients included, propensity score matched Cox regression showed greater risk of all-cause mortality among high dose recipients IJID regions31-42https://www.ebi.ac.uk/biostudies/studies/S-EPMC9492392biostudies-literatureTreatment Outcome with High versus low-to-moderate Dosing of Corticosteroids in Early vis-a-vis Late-onset Hypoxic Cases of COVID-19: A Multicentric Retrospective Cohort Study.PMC9492392Ghosh DBiswas SDas SGowsami DNMukherjee AKumar SMitra MSaha AKBiswas DBasu SShamim SChakraborty RTodi SKSain BfalseTreatment Outcome with High versus low-to-moderate Dosing of Corticosteroids in Early vis-a-vis Late-onset Hypoxic Cases of COVID-19: A Multicentric Retrospective Cohort Study.<h4>Background</h4>Corticosteroid dosing in COVID-19 cases associated with early-onset and late-onset hypoxia have not been separately explored.<h4>Methods</h4>In this retrospective cohort study, we divided hypoxic COVID-19 cases into groups based on timing of initiation of corticosteroids relative to onset of symptoms; Group A (≤6th day), Group B (7th-9th day) and Group C (≥10th day), each group being sub-grouped into high and low-to-moderate dose corticosteroid recipients. Cox regression with propensity scoring was used to compare 28-day mortality between high and low-to-moderate dose recipients separately in Group A, Group B, Group C.<h4>Results</h4>Among 505 patients included, propensity score matched Cox regression showed greater risk of all-cause mortality among high dose recipients 2023-01-01T00:00:00Z2023 Jun2025-04-03T21:30:36.564Z2025-04-03T21:30:36.564ZS-EPMC94923923616434410.1016/j.ijregi.2022.09.007