biostudies-literatureBrashear AMNIAID NIH HHSNational Institutes of Health984394https://www.ebi.ac.uk/biostudies/studies/S-EPMC9493318biostudies-literatureUnknown13Malaria elimination includes neglected human malaria parasites Plasmodium vivax, Plasmodium ovale spp., and Plasmodium malariae. Biological features such as association with low-density infection and the formation of hypnozoites responsible for relapse make their elimination challenging. Studies on these parasites rely primarily on clinical samples due to the lack of long-term culture techniques. With improved methods to enrich parasite DNA from clinical samples, whole-genome sequencing of the neglected malaria parasites has gained increasing popularity. Population genomics of more than 2200 P. vivax global isolates has improved our knowledge of parasite biology and host-parasite interactions, identified vaccine targets and potential drug resistance markers, and providFrontiers in microbiologyPopulation genomics in neglected malaria parasites.PMC9493318U19 AI089672Brashear AMCui LfalsePopulation genomics in neglected malaria parasites.Malaria elimination includes neglected human malaria parasites Plasmodium vivax, Plasmodium ovale spp., and Plasmodium malariae. Biological features such as association with low-density infection and the formation of hypnozoites responsible for relapse make their elimination challenging. Studies on these parasites rely primarily on clinical samples due to the lack of long-term culture techniques. With improved methods to enrich parasite DNA from clinical samples, whole-genome sequencing of the neglected malaria parasites has gained increasing popularity. Population genomics of more than 2200 P. vivax global isolates has improved our knowledge of parasite biology and host-parasite interactions, identified vaccine targets and potential drug resistance markers, and provid2022-01-01T00:00:00Z20222025-08-31T03:18:35.752Z2025-04-05T12:32:13.064ZS-EPMC94933183616025710.3389/fmicb.2022.984394