biostudies-literatureUnknown12Lasagni S<h4>Background</h4>Though the precise criteria for accessing LT are consistently being applied, HCC recurrence (HCC-R_LT) still affects more than 15% of the patients. We analyzed the clinical, histopathological, and biological features of patients with HCC to identify the predictive factors associated with cancer recurrence and survival after LT.<h4>Methods</h4>We retrospectively analyzed 441 patients with HCC who underwent LT in our center. Overall, 70 (15.8%) of them developed HCC-R_LT. We matched them by age at transplant and etiology with 70 non-recurrent patients. A comparable cohort from the Liver Transplant Centre of Bologna served as validation. The clinical and biochemical characteristics and pre-LT criteria (Milan, Metroticket, Metroticket_AFP, and AFP model) were evaluated. HistFrontiers in oncology960808https://www.ebi.ac.uk/biostudies/studies/S-EPMC9493368biostudies-literatureEndothelial angiopoietin-2 overexpression in explanted livers identifies subjects at higher risk of recurrence of hepatocellular carcinoma after liver transplantation.PMC9493368Gitto Sd'Errico ALeonardi FRomagnoli DPivetti AGiannelli GRomanzi ASerenari MCatellani BDituri FCritelli RMMartinez-Chantar MLColecchia ACelsa CMancarella Sdi Benedetto FCamma CRiefolo MLasagni SEnea MDi Marco LSchepis FRavaioli FMilosa Fde Maria NCescon MVilla EMagistri PfalseEndothelial angiopoietin-2 overexpression in explanted livers identifies subjects at higher risk of recurrence of hepatocellular carcinoma after liver transplantation.<h4>Background</h4>Though the precise criteria for accessing LT are consistently being applied, HCC recurrence (HCC-R_LT) still affects more than 15% of the patients. We analyzed the clinical, histopathological, and biological features of patients with HCC to identify the predictive factors associated with cancer recurrence and survival after LT.<h4>Methods</h4>We retrospectively analyzed 441 patients with HCC who underwent LT in our center. Overall, 70 (15.8%) of them developed HCC-R_LT. We matched them by age at transplant and etiology with 70 non-recurrent patients. A comparable cohort from the Liver Transplant Centre of Bologna served as validation. The clinical and biochemical characteristics and pre-LT criteria (Milan, Metroticket, Metroticket_AFP, and AFP model) were evaluated. Hist2022-01-01T00:00:00Z20222025-04-05T12:32:32.945Z2025-04-05T12:32:32.945ZS-EPMC94933683615865110.3389/fonc.2022.960808