biostudies-literatureUnknown79(11)Kendler KS<h4>Importance</h4>The nature of the genetic relationship between major depression and bipolar disorder remains unclear and might be clarified by considering disorders outside of the mood spectrum.<h4>Objective</h4>To better understand the relationship between genetic liabilities for major depression (MD) and bipolar disorder (BD).<h4>Design, setting, and participants</h4>A cohort study was conducted with data for individuals born in Sweden to Swedish parents from 1960 to 1990, with follow-up through December 31, 2018. The data included family genetic risk scores for MD and BD and International Classification of Diseases codes for a range of disorders as reported in primary care, specialist, and hospital registries. Data analysis was conducted from April 2022 to July 2022.<h4>Exposures</h4JAMA psychiatry1102-1109https://www.ebi.ac.uk/biostudies/studies/S-EPMC9494271biostudies-literatureRisk for Mood, Anxiety, and Psychotic Disorders in Individuals at High and Low Genetic Liability for Bipolar Disorder and Major Depression.PMC9494271Sundquist JSundquist KOhlsson HKendler KSfalseRisk for Mood, Anxiety, and Psychotic Disorders in Individuals at High and Low Genetic Liability for Bipolar Disorder and Major Depression.<h4>Importance</h4>The nature of the genetic relationship between major depression and bipolar disorder remains unclear and might be clarified by considering disorders outside of the mood spectrum.<h4>Objective</h4>To better understand the relationship between genetic liabilities for major depression (MD) and bipolar disorder (BD).<h4>Design, setting, and participants</h4>A cohort study was conducted with data for individuals born in Sweden to Swedish parents from 1960 to 1990, with follow-up through December 31, 2018. The data included family genetic risk scores for MD and BD and International Classification of Diseases codes for a range of disorders as reported in primary care, specialist, and hospital registries. Data analysis was conducted from April 2022 to July 2022.<h4>Exposures</h42022-01-01T00:00:00Z2022 Nov2025-04-19T17:22:04.813Z2025-04-19T17:22:04.813ZS-EPMC94942713612971610.1001/jamapsychiatry.2022.2873