{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Needham EJ"],"funding":["NIHR Cambridge Biomedical Centre","Brain Research UK","European Research Council","Medical Research Council","National Institute for Health Research (NIHR)","Rosetrees","Wellcome Trust","Academy of Medical Sciences"],"pagination":["4097-4107"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9494359"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["145(11)"],"pubmed_abstract":["COVID-19 is associated with neurological complications including stroke, delirium and encephalitis. Furthermore, a post-viral syndrome dominated by neuropsychiatric symptoms is common, and is seemingly unrelated to COVID-19 severity. The true frequency and underlying mechanisms of neurological injury are unknown, but exaggerated host inflammatory responses appear to be a key driver of COVID-19 severity. We investigated the dynamics of, and relationship between, serum markers of brain injury [neurofilament light (NfL), glial fibrillary acidic protein (GFAP) and total tau] and markers of dysregulated host response (autoantibody production and cytokine profiles) in 175 patients admitted with COVID-19 and 45 patients with influenza. During hospitalization, sera from patients with COVID-19 demo"],"journal":["Brain : a journal of neurology"],"pubmed_title":["Brain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses."],"pmcid":["PMC9494359"],"funding_grant_id":["MR/R005036/1","ACF-2022-26-005","NIHR200256","NIHR201395","AMS-CSF4-Newcombe","COV-LT2-0004","090382/Z/09/Z","MR/V03605X/1","M957","104079/Z/14/Z","MR/V007181/1","720931","CL-2018-14-001","ACF-2009-14-007","MR/V007173/1","NF-SI-0513-10051","MR/T028750/1","681712","COVID-19-RECPLAS","201819-20","MC_G0802534"],"pubmed_authors":["Samanta RJ","Allison J","Stark H","Anwar F","Pascuale C","Phelan I","Rossi S","Taylor J","Ocaya C","Christmas D","Cossetti C","Hinch A","Publico C","Bradley JR","Josipovic M","Perales M","Perera M","Walker N","Hall G","Fahey C","Hein S","Calder J","Ivers T","Irani SR","Yakovleva A","Epping M","Ashton NJ","Dougan G","Mescia F","Laurenti E","Ansaripour A","Clapham-Riley D","Summers C","Georgana I","Yarkoni NS","Matara C","Hosmillo M","Curran M","Jones E","George A","Jones H","Zerrudo CYAJ","Bhatti J","Jubb AW","Cruz I","Lyons PA","Hamilton W","Turner L","McMahon C","Ren AL","Parmar S","Linger R","Lehner PJ","Rowe JB","Paraschiv R","Ziegenweidt JV","Gray J","Jose S","Bermperi A","Bergamaschi L","Worsley J","Marsden J","Pinckert M","Bullman B","Ruffolo V","Sithole N","Weekes MP","Papadia S","Zetterberg H","Cavanagh J","Bullmore ET","Caller L","Biggs H","Saunders C","Williams GB","Sambrook J","Dunai C","Jarvis I","Ranganath V","Stamatakis EA","Tordesillas H","Sharma R","Eden A","Li E","Alvio G","Coles AJ","Gupta RK","Townsend P","Jesus R","Lewis D","Spencer S","Norton EJ","Canna L","Bong SH","Gresley EL","Brookes K","Chaudhry Y","Hewitt S","Rowlands J","Dempsey K","Toshner M","Digby RJ","Doffinger R","Jackson S","Thaventhiran JED","Kasanicki M","Meloy S","O'Donnell C","Mende N","Shih J","Mwaura L","Harris J","Furlong A","Pointon L","Dunmore BJ","Chatfield DA","Newcombe VFJ","Houldcroft C","O'Brien C","Patterson C","Ebrahimi S","Wilson NK","Chinnery P","Polwarth G","Stefanucci L","Kennet J","Stefano GD","Martin J","Domingo J","Huhn O","Hunter K","Chandler M","Lupson VC","Omarjee O","Chinnery PF","Sa A","Moulton A","Manktelow AE","Fawke S","Gleadall N","Kourampa J","Michell A","Richoz N","Marioni JC","Graf S","Gisslen M","Sutcliffe R","Coles JP","Dunning J","Griffiths MJ","Meadows A","Bunclark K","Caddy S","Selvan M","Burnstein RM","Muldoon F","Vargas P","Price J","Taussig MJ","Tong Z","Kingston N","Fernandez C","Wood J","Nice F","CITIID-NIHR COVID-19 BioResource Collaboration","Baker S","Fonseca C","Mackay M","Valerio F","Polgarova P","Hess C","Huang C","Correia M","Meredith L","Stephens J","Rastall R","Spindler LRB","Grenfell R","Watson L","Mendoza V","Hodgson J","Michael A","Bie EMDD","Smith KGC","Caputo D","Strezlecki M","Cambridge NeuroCOVID Group","Rodgers CT","Taams LS","Holmes E","Treacy C","Elmer A","Fletcher PC","Butcher H","Wylot M","Tilly T","Webster J","Breen G","Ribeiro C","Leibowitz MM","Penkett C","Allinson K","Openshaw PJM","Rua C","Michel R","Bower G","Owehand WH","Needham EJ","Outtrim JG","Schon K","Widmer B","Das T","King Y","Dewhurst E","Romashova V","Okecha G","Feltwell T","Pond N","Crucusio C","Betancourt A","Legchenko E","Stirrups KE","Khokhar F","Menon DK","Marklund E","Jahun A","Goodfellow IG","Cambridge NIHR Clinical Research Facility","Bucke A","Michael BD","Ovington N","Dean AM","Fuller S","Vergese B","Cooper D","Coudert JD","Matheson NJ","Barcenas-Morales G","Graves B"],"additional_accession":[]},"is_claimable":false,"name":"Brain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses.","description":"COVID-19 is associated with neurological complications including stroke, delirium and encephalitis. Furthermore, a post-viral syndrome dominated by neuropsychiatric symptoms is common, and is seemingly unrelated to COVID-19 severity. The true frequency and underlying mechanisms of neurological injury are unknown, but exaggerated host inflammatory responses appear to be a key driver of COVID-19 severity. We investigated the dynamics of, and relationship between, serum markers of brain injury [neurofilament light (NfL), glial fibrillary acidic protein (GFAP) and total tau] and markers of dysregulated host response (autoantibody production and cytokine profiles) in 175 patients admitted with COVID-19 and 45 patients with influenza. During hospitalization, sera from patients with COVID-19 demo","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2026-06-18T07:02:17.852Z","creation":"2025-04-07T09:57:33.429Z"},"accession":"S-EPMC9494359","cross_references":{"pubmed":["36065116"],"doi":["10.1093/brain/awac321"]}}