biostudies-literatureUnknown12Wang J<h4>Objective</h4>The progress of neoadjuvant therapy for resectable locally advanced esophageal cancer has been stagnant. There has been much progress in immunotherapy for advanced esophageal cancer, but the efficacy and safety of neoadjuvant immunotherapy for resectable locally advanced esophageal cancer have not yet been definitively demonstrated.<h4>Methods</h4>Original articles describing the safety and efficacy of neoadjuvant immunotherapy in resectable locally advanced esophagus published until July 2022 were retrieved from PubMed, Embase, and the Cochrane Library. The ratio (OR) and 95% confidence interval (CI) were calculated to conduct heterogeneity and subgroup analysis.<h4>Results</h4>In total, 759 patients from 21 studies were enrolled. The effectiveness of neoadjuvant immunotFrontiers in oncology974684https://www.ebi.ac.uk/biostudies/studies/S-EPMC9495441biostudies-literatureEfficacy and safety of neoadjuvant immunotherapy combined with chemotherapy in locally advanced esophageal cancer: A meta-analysis.PMC9495441Liu YLi JZhang KHua PLiu TChen SWang JZhao YSong YfalseEfficacy and safety of neoadjuvant immunotherapy combined with chemotherapy in locally advanced esophageal cancer: A meta-analysis.<h4>Objective</h4>The progress of neoadjuvant therapy for resectable locally advanced esophageal cancer has been stagnant. There has been much progress in immunotherapy for advanced esophageal cancer, but the efficacy and safety of neoadjuvant immunotherapy for resectable locally advanced esophageal cancer have not yet been definitively demonstrated.<h4>Methods</h4>Original articles describing the safety and efficacy of neoadjuvant immunotherapy in resectable locally advanced esophagus published until July 2022 were retrieved from PubMed, Embase, and the Cochrane Library. The ratio (OR) and 95% confidence interval (CI) were calculated to conduct heterogeneity and subgroup analysis.<h4>Results</h4>In total, 759 patients from 21 studies were enrolled. The effectiveness of neoadjuvant immunot2022-01-01T00:00:00Z20222025-04-05T12:10:41.256Z2025-04-05T12:10:41.256ZS-EPMC94954413615867910.3389/fonc.2022.974684