{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lamin V"],"funding":["NIA NIH HHS","NHLBI NIH HHS"],"pagination":["e025727"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9496313"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(16)"],"pubmed_abstract":["Background Peripheral artery disease is caused by atherosclerotic occlusion of vessels outside the heart and most commonly affects vessels of the lower extremities. Angiogenesis is a part of the postischemic adaptation involved in restoring blood flow in peripheral artery disease. Previously, in a murine hind limb ischemia model of peripheral artery disease, we identified ADAM12 (a disintegrin and metalloproteinase gene 12) as a key genetic modifier of postischemic perfusion recovery. However, less is known about ADAM12 regulation in ischemia. MicroRNAs are a class of small, noncoding, single-stranded RNAs that regulate gene expression primarily through transcriptional repression of messenger RNA (mRNA). We showed microRNA-29a (miR-29a) modulates ADAM12 expression in the setting of diabete"],"journal":["Journal of the American Heart Association"],"pubmed_title":["microRNA-29a Regulates ADAM12 Through Direct Interaction With ADAM12 mRNA and Modulates Postischemic Perfusion Recovery."],"pmcid":["PMC9496313"],"funding_grant_id":["R56 AG063820","R01 HL130399"],"pubmed_authors":["Wong T","Lamin V","Kronemberger A","Dokun OS","Lira VA","Dokun AO","Verry J"],"additional_accession":[]},"is_claimable":false,"name":"microRNA-29a Regulates ADAM12 Through Direct Interaction With ADAM12 mRNA and Modulates Postischemic Perfusion Recovery.","description":"Background Peripheral artery disease is caused by atherosclerotic occlusion of vessels outside the heart and most commonly affects vessels of the lower extremities. Angiogenesis is a part of the postischemic adaptation involved in restoring blood flow in peripheral artery disease. Previously, in a murine hind limb ischemia model of peripheral artery disease, we identified ADAM12 (a disintegrin and metalloproteinase gene 12) as a key genetic modifier of postischemic perfusion recovery. However, less is known about ADAM12 regulation in ischemia. MicroRNAs are a class of small, noncoding, single-stranded RNAs that regulate gene expression primarily through transcriptional repression of messenger RNA (mRNA). We showed microRNA-29a (miR-29a) modulates ADAM12 expression in the setting of diabete","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-04T12:04:35.338Z","creation":"2025-04-04T12:04:35.338Z"},"accession":"S-EPMC9496313","cross_references":{"pubmed":["35946473"],"doi":["10.1161/JAHA.122.025727"]}}