{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Du H"],"funding":["National Natural Science Foundation of China"],"pagination":["2725"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9498142"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(18)"],"pubmed_abstract":["<i>Pichia kudriavzevii</i> plays an important role in fermented foods and beverages. In the long domestication process of traditional fermentation, the mechanism of response to lactic acid, a common metabolite and growth inhibitor, is currently unclear in <i>P. kudriavzevii</i>. In this study, the tolerance to lactic acid of <i>P. kudriavzevii</i> C-16, isolated from fermented grains, was compared with its type strain ATCC 24210. Under lactic acid stress, <i>P. kudriavzevii</i> C-16 showed increased biomass yields and lactic acid consumption rates. Then, mRNA sequencing was used to analyze the response to lactic acid in <i>P. kudriavzevii</i> C-16. Results showed that 92 and 96 genes were significantly upregulated, 52 and 58 genes were significantly downregulated, respectively, in <i>P. ku"],"journal":["Foods (Basel, Switzerland)"],"pubmed_title":["Transcriptional Profiling Reveals Adaptive Response and Tolerance to Lactic Acid Stress in <i>Pichia kudriavzevii</i>."],"pmcid":["PMC9498142"],"funding_grant_id":["32172176"],"pubmed_authors":["Deng N","Du H","Fu Y","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptional Profiling Reveals Adaptive Response and Tolerance to Lactic Acid Stress in <i>Pichia kudriavzevii</i>.","description":"<i>Pichia kudriavzevii</i> plays an important role in fermented foods and beverages. In the long domestication process of traditional fermentation, the mechanism of response to lactic acid, a common metabolite and growth inhibitor, is currently unclear in <i>P. kudriavzevii</i>. In this study, the tolerance to lactic acid of <i>P. kudriavzevii</i> C-16, isolated from fermented grains, was compared with its type strain ATCC 24210. Under lactic acid stress, <i>P. kudriavzevii</i> C-16 showed increased biomass yields and lactic acid consumption rates. Then, mRNA sequencing was used to analyze the response to lactic acid in <i>P. kudriavzevii</i> C-16. Results showed that 92 and 96 genes were significantly upregulated, 52 and 58 genes were significantly downregulated, respectively, in <i>P. ku","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-22T04:07:54.014Z","creation":"2025-04-05T20:55:52.791Z"},"accession":"S-EPMC9498142","cross_references":{"pubmed":["36140854"],"doi":["10.3390/foods11182725"]}}