biostudies-literatureDel Coso JEuropean University of MadridFrancisco de Vitoria UniversityMiguel Hernandez University1635https://www.ebi.ac.uk/biostudies/studies/S-EPMC9498709biostudies-literatureUnknown13(9)The p.R577X polymorphism (rs1815739) in the <i>ACTN3</i> gene causes individuals with the XX genotype to be deficient in functional α-actinin-3. Previous investigations have found that XX athletes are more prone to suffer non-contact muscle injuries, in comparison with RR and RX athletes who produce a functional α-actinin-3 in their fast-twitch fibers. This investigation aimed to determine the influence of the <i>ACTN3</i> R577X polymorphism on physical performance and injury incidence of players competing in the women's Spanish first division of football (soccer). Using a cross-sectional experiment, football-specific performance and epidemiology of non-contact football-related injuries were recorded in a group of 191 professional football players. <i>ACTN3</i> R577X genotype was obtained GenesAssociation of the <i>ACTN3</i> rs1815739 Polymorphism with Physical Performance and Injury Incidence in Professional Women Football Players.PMC9498709000100001Iztueta ABuil MASanchez-Sanchez JRodas GDel Coso JGonzalez-Rodenas JGasulla-Angles PLopez-Samanes AHernandez-Sanchez SMoreno-Perez VLopez PfalseAssociation of the <i>ACTN3</i> rs1815739 Polymorphism with Physical Performance and Injury Incidence in Professional Women Football Players.The p.R577X polymorphism (rs1815739) in the <i>ACTN3</i> gene causes individuals with the XX genotype to be deficient in functional α-actinin-3. Previous investigations have found that XX athletes are more prone to suffer non-contact muscle injuries, in comparison with RR and RX athletes who produce a functional α-actinin-3 in their fast-twitch fibers. This investigation aimed to determine the influence of the <i>ACTN3</i> R577X polymorphism on physical performance and injury incidence of players competing in the women's Spanish first division of football (soccer). Using a cross-sectional experiment, football-specific performance and epidemiology of non-contact football-related injuries were recorded in a group of 191 professional football players. <i>ACTN3</i> R577X genotype was obtained 2022-01-01T00:00:00Z2022 Sep2025-04-21T14:52:38.945Z2025-04-21T14:52:38.945ZS-EPMC94987093614080310.3390/genes13091635